Senior Scientist, In Vivo Metabolism Bioscience
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Posted on:
22 hours ago
Vacancies:
1 Vacancy
Job Summary
We invite you to bring your hands-on in vivo pharmacology expertise to advance metabolic disease drug discovery within AstraZenecas Metabolism Bioscience division in this lab-based role you will lead end-to-end in vivo strategy and execution from study design to will drive high-quality rodent studies that enable therapies for diabetes obesity MASH and cardiovascular disease from target validation to IND supporting packages.
Metabolism Bioscience is part of Early Cardiovascular Renal and Metabolism (CVRM) one of AstraZenecas three main therapeutic areas delivering candidate drugs into clinical development. Our Metabolism Bioscience department is a highly collaborative cross-functional team dedicated to scientific excellence and innovation. You will work in a dynamic matrixed environment alongside experts in several functions including DMPK Chemistry Clinical Pharmacology and Safety Sciences Pharmaceutical Sciences Translational Science and Clinical Development with the opportunity to shape strategy and directly influence portfolio progression across early discovery and late-stage enabling studies.
Accountability
Lead in vivo strategy and execution: Serve as the in vivo lead on bioscience project teams. Partner closely with cross functional teams to set study design and decision paths aligned to project objectives and governance milestones.
Own end-to-end study delivery: Independently plan execute analyze and present in vivo studies from hypothesis and protocol through data interpretation and governance interactions ensuring rigor reproducibility and clear go/no-go recommendations.
Author high-impact documentation: Contribute to manuscripts posters and internal/external presentations. Write regulatory-grade reports for IND/CTA packages.
Advance models and methods: Develop qualify and continuously improve in vivo models and translational methods aligned to early CVRM strategy including fit-for-purpose endpoints and biomarkers that accelerate portfolio decisions.
Essential requirements
Education: MSc in relevant discipline or equivalent experience and current certification for in vivo experimentation (e.g. FELASA or equivalent).
Communication: Strong oral and written communication skills in English; Swedish desirable but not required. Willingness to author and own Swedish ethical applications.
Advanced rodent in vivo expertise: Proficiency in mouse and rat handling; multiple dosing routes (PO IV SC); blood/tissue sampling (tail vein retro-orbital terminal). Experience with metabolic phenotyping (OGTT IPGTT IVGTT); surgical skills desirable.
Metabolic study design and interpretation: Hands-on experience (within the past 12 years) with obesity T2D MASH/MAFLD and dyslipidemia models. Deep understanding of how stress circadian rhythm diet handling and environment influence outcomes and variability.
Translational mindset: Proven ability to design studies that answer clear project questions from early mechanism of action/target validation through doseresponse PK/PD and efficacy packages that enable pipeline progression.
Cross-functional leadership: Track record of leading study design and delivery with internal partners and CROs meeting timelines quality welfare and compliance standards.
Data-to-decision: Ability to distil complex in vivo data into actionable insights for diverse audiences informing strategy milestones and regulatory narratives.
Growth and curiosity: Drive to expand knowledge in metabolic disease biology emerging models and advanced readouts (e.g. indirect calorimetry body composition) and to adopt innovations that improve translational relevance.
At AstraZeneca we are committed to making a difference for patients. We fuse data and technology with cutting-edge science to achieve the next wave of breakthroughs. Our culture values curiosity and courage and we work seamlessly across academia biotechs and industry to deliver the greatest impact on Gothenburg youll join an international open and creative R&D community that fosters collaboration development and scientific excellence.
If your passion is science and you want to turn in vivo insights into medicines that improve patients lives apply now.
Submit your application by March 31st 2026
Date Posted
18-mars-2026Closing Date
31-mars-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
