Scientist (Protein Expression and Large-Scale Purification)
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Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
Introduction to role:
Are you ready to scale recombinant proteins from 50500 L and see your work translate into clinical readiness Do you thrive at the interface of hands-on experimentation and pilot-scale decision making that speeds life-changing medicines to patients
As a Scientist in Protein Expression and Large-Scale Purification you will join a cross-functional team focused onprogressingbiologics from lab to pilot scale with precision pace and scientific rigor. Your work will underpin toxicology supply informclinicalmanufacturing strategies and advance novel technologies that make our processes faster more robust and more sustainable.
You will collaborate with experts across processdevelopment analytical sciencesand formulation working with modern pilot-scale systems to build scalable high-quality purification processes. Your impact will be visible in the speed and quality of programs entering the clinicand in the technologieswe develop for the next generation of biologics.
Accountabilities:
Primary Clarification Operations: Lead primary clarification of 50500 L bioreactors using disk stack centrifugation and depth filtration.
Pilot-Scale Purification: Run recombinant protein purification on Bioprocess and AKTA pilot-scale systems.
Polishing Development: Design and implement polishing steps to enrich purity and remove process- and product-related impurities increasing product quality.
Scale-Up for Clinical Readiness: Execute detailed production at scale prior to clinical manufacture generating data thatsupportstech transfer.
Ultrafiltration/Diafiltration: Perform UF/DF using bench and pilot-scale systems to achieve target concentration and buffer conditions while maintaining product integrity.
Analytics and Characterization: Apply SEC-HPLC UV-Vis osmolarity and related techniques to characterize process performance enabling data-driven decisions.
Technology Development: Contribute to in-house technology development projectsto elevate capability reduce cost and increase speed to clinic.
Data Integrity and Reporting: Record experiments accurately and on time; produce clear data summaries and reports that drive program decisions and meet project timelines.
Scientific Communication: Present results and recommendations at group and departmental forums fostering discussion that sharpens strategy and execution.
Mentorship and Collaboration: Oversee and mentor students from placements or academic collaborations; cultivate productive collaborations internally and with external partners.
Health Safety and Compliance:Implement and promote AstraZenecas health and safety practices including the regulations governing COSHH biological agents and genetically modified organisms as detailed in the relevant risk assessments.
Toxicology and Pilot Support: Play a significant role in tox supply activities and pilot-scale primary clarification purification and formulation to keep critical milestones on track.
Essential Skills/Experience:
Qualifications: Relevant university degree (e.g. BSc/MSc/PhD) in Life Science Chemical or Bioprocess Engineering with relevant industrial experience desirable.
Technical and practical understanding of Protein purifications at 50-500L scale
The use of Centrifuge and POD filtration as well as Bioprocess and AKTA pilot and associated software
Development of polishing steps for purity enrichment
Ultrafiltration/Diafiltration using bench and pilot scale systems
Product and process characterization using SEC-HPLC UV-VIS Osmolarity device and other techniques
Contributing to technology development projects.
Accurate clear and timely recording of experiments; preparation of data summaries and reports according to project requirements and timelines
Presentation of data at informal group meetings and at departmental meetings
Desirable Skills/Experience:
Experience of HPLC
Experience preparing batch records
Process filter sizing
Experience large scale Tangential Flow Filtration
Large scale column packing
Experience in mammalian cell culture and protein expression
Operation of bioreactor systems for mammalian suspension cultures
Experience in the use of data science and AI/ML tools for process development and data analysis (JMP / foundation and agentbased AI assistants)
Why AstraZeneca:
At AstraZeneca curious minds come together to do work that matters. We collaborate in crossfunctional teamsspanning early discovery process development analytical sciences and moreto transform molecules into medicines for patients. Join a leading R&D organization pushing scientific boundaries with the latest tools and data. You will be empowered to ask bold questions learn quickly from experiments and shape how breakthrough biologics reach patientssupported by leaders who value kindness alongside ambition and by teams that share knowledge openly to move with speed and purpose.
Call to Action:
If you are ready to turn pilot-scale protein purification into real clinicalprocesses bring your expertise and ambition to AstraZeneca and help us deliver the next wave of life-changing medicines.
Date Posted
16-mar.-2026Closing Date
31-mar.-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
IC
Key Skills
- Laboratory Experience
- Immunoassays
- Machine Learning
- Biochemistry
- Assays
- Research Experience
- Spectroscopy
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Data Analysis Skills
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
