Research Technologist I Ma Lab

Versiti is a fusion of donors scientific curiosity and precision medicine that recognize the gifts of blood and life are precious. We are home to the world-renowned Blood Research Institute we enable life saving gifts from our donors and provide the science behind the medicine through our diagnostic laboratories. Versiti brings together outstanding minds with unparalleled experience in transfusion medicine transplantation stem cells and cellular therapies oncology and genomics diagnostic lab services and medical and scientific expertise. This combination of skill and knowledge results in improved patient outcomes higher quality services and reduced cost of care for hospitals blood centers hospital systems research and educational institutions and other health care providers. At Versiti we are passionate about improving the lives of patients and helping our healthcare partners thrive.

Performs laboratory assays and complex experiments to elucidate novel research questions.

The Ma Lab studiesintegrin signaling in blood cells. Integrin family receptors deliver bidirectional signaling (inside-out and outside-in) across the cell plasma membrane modulating cell adhesion migration proliferation differentiation and other functions. Integrin signaling involves a series of molecular events within cells that enable integrins to bridge the crosstalk between the extracellular milieu and cytoskeletal changes as well as cytoplasmic signaling cascades. Integrin activation is tightly regulated by integrin cytoplasmic tail binding proteins (ICBPs). The interaction between integrins and ICBPs defines the activation states and functional activities of integrins. Dysfunction of integrin signaling often leads to integrin-associated pathological conditions including inflammatory defects and bleeding disorders. The long-term goal of our research is to elucidate the detailed molecular mechanisms regulating integrin signaling and to explore novel and safer therapeutic strategies for preventing and treating integrin-associated diseases such as inflammation and thrombosis.

The ongoing research in our laboratory focuses on Kindlin-3 an essential integrin signaling adaptor molecule and one of the key ICBPs expressed in cells of hematopoietic origin. Kindlin-3 plays a critical role in supporting integrin signaling in blood cells. Kindlin-3 deficiency causes type-III leukocyte adhesion deficiency (LAD-III) in humans characterized by severe bleeding disorders and recurrent infections. Specifically we are investigating the novel role of Kindlin-3 in platelets and myeloid cells in modulating immunothrombosis under various pathological conditions including deep vein thrombosis and endotoxemia. Our experimental approaches range from biochemical and cellular analyses to small animal models. Our study may facilitate the development of more specific and safer strategies for treating immunothrombotic complications across a wide range of diseases.

Benefits
Versiti provides a comprehensive benefits package based on your job classification. Full-time regular employes are eligible for Medical Dental and Vision Plans Paid Time Off (PTO) and Holidays Short- and Long-term disability life insurance 7% match dollar for dollar 401(k) voluntary programs discount programs others.

• Works with Principal Investigator to plan structure and execute research experiments.
• Troubleshoots assays and customizes experimental tools
• Coordinates external and internal resources necessary for completion of research plan
• Generates clear and complete records of experimental work
• Participates in publication of research results
• Performs other duties as required or assigned to technically support scientific projects in the lab and other tasks that are assigned by Principal Investigator
• Performs other duties as required or assigned which are reasonably within the scope of the duties in this job classification
• Understands and performs in accordance with all applicable regulatory and compliance requirements
• Complies with all standard operating policies and procedures

Education

• Bachelors Degree from an accredited college or university in biology chemistry or equivalent scientific discipline required

Experience

• 1-3 years relevant laboratory experience required

Knowledge Skills and Abilities

• Knowledge of theoretical basis of work being performed preferred
• Ability to work independently with minimum supervision required
• Proficient in research laboratory techniques required
• Strong detail orientation and analytical ability required
• Ability to accurately carry out experiments and tasks by following established guidelines required
• Ability to prioritize and execute multiple tasks required
• Effective organizational and communication skills required

Tools and Technology

• Personal computer required
• Specialized research equipment preferred

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