Global Head Mechanistic Safety and Safety Signal Management

Job Description Summary

Job Description

Major accountabilities:

- Lead enterprise-wide mechanistic safety strategy toanticipate evaluate and address emerging safety risks.

- Chair the Medical Safety Review Board to guide rapid and scientifically sound safety decision-making.

- Provide expert leadership across development teams to strengthen safety insights from early research to post-marketing.

- Drive mechanistic investigation of safety signals to inform confident project progression and risk mitigation.

- Oversee coordination of mechanistic activities across development translational research and clinical functions.

-Guidecreation review and improvement of Risk Management Plans and safety mitigation strategies.

- Evaluate safety findings from preclinical and clinical projects todeterminetheir translational significance.

- Foster collaboration with safety expert panels and ensure highest standards of scientific quality.

- Lead and develop mechanistic safety associates nurturingexpertiseand scientific excellence.

- Build impactful internal and external partnerships to advance innovative safety methodologies and best practices.

Minimum Requirements:

- Medical degree with strong grounding in clinical sciences and patient safety.

- Fluent English (both spoken and written).

- Experience in the conduct of clinical trials phases 1 2 3.

- Extensive experience in drug development across preclinical and clinical stages in the pharmaceutical industry.

- Provenexpertisein preparing or contributing to clinical and safety assessments and regulatory safety submissions.

-Demonstratedleadership in guiding cross-functional and multicultural teams within a matrix environment.

- Strong capability in managing complex safety issues using scientific methodological and analytical principles.

- Deep understanding of clinical trialmethodology regulatory expectations scientific approaches and publication development.

- Track record of peer-reviewed scientific publicationsdemonstratinghigh scientific quality andexpertise.

- Exceptional communication and stakeholder engagement skills to influence decision-making at all organizational levels.

Desirable Skills:

- Specialty Board Certification ina relevant medical field such as Internal Medicine Clinical Pharmacology and Toxicology Gastroenterology or Cardiology.

- Understanding of anadditionalmajor language such as German or French to support cross-regional collaboration.

-Additionalexperience working with statistical methods to strengthen scientific evaluation and interpretation.

Accessibility and accommodation

Novartis is committed to working with and providing reasonable accommodation to all individuals. If because of a medical condition or disability you need a reasonable accommodation for any part of the recruitment process or in order to receive more detailed information about the essential functions of a position please send an e-mail to and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Next Steps

If you are inspired by the opportunity to shape global safety strategy and advance scientific excellence at scale we encourage you to apply. Join us and bring your vision leadership andexpertiseto a role where your impact truly protects patients and shapes the future of healthcare.

Latest date for applications: 23 March 2026

Job posting closes: 24 March 2026

Skills Desired