Postdoctoral Position in Cryo-Electron Tomography of Systemic Amyloidosis
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Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
About the project
Systemic amyloidosis comprises severe protein misfolding diseases in which amyloid fibrils accumulate across multiple organs leading to progressive dysfunction. AL (lightchain) and ATTR (transthyretin) amyloidosis are the most common systemic forms with distinct molecular origins but shared mechanisms of extracellular amyloid deposition and tissue damage.
Our research program focuses on understanding the molecular and cellular mechanisms of systemic amyloid deposition with particular emphasis on AL and ATTR amyloidosis. We use in situ structural approaches to visualize amyloid assemblies and their cellular interactions supported by strong clinical collaborations and access to wellcharacterized patient samples.
We are seeking a highly motivated Postdoctoral Researcher to apply cryoelectron tomography (cryoET) to study in situ amyloid deposition and amyloidcell interactions in experimental models and human tissues. This project is part of the VIB Grand Challenges initiative which is building a national reference framework for systemic amyloidosis and promoting translational research to improve diagnosis and patient care.
About the lab
The SWITCH Laboratory is a leading center for research on protein aggregation in human disease. We are an interdisciplinary team of 25 researchers with expertise spanning bioinformatics biophysics and cell biology. SWITCH hosts a unique suite of technologies for studying protein aggregation including advanced biophysical ultrastructural and cellbiological platforms.
Learn more about us on our website and dont miss the laboratory section to explore our state-of-the-art infrastructure!
About the role
The successful candidate will use state-of-the-art cryo-ET to investigate amyloid formation organization and interactions across multiple biological systems.
- Evaluation of cellular and animal models of systemic amyloidosis
- Visualization of amyloid deposition and interactions in situ at molecular resolution
- Comparative analysis across experimental models and patient-derived specimens
- Extension of these observations to clinical samples from patients with systemic amyloidosis including ATTR and AL amyloidosis
- Integration of cryo-ET subtomogram averaging and structural analysis to postulate a mechanistic framework for systemic amyloid deposition and pathology
This project bridges structural biology cell biology and translational disease research and offers strong opportunities for methodological development interdisciplinary collaboration and high-impact publications.
Your profile
We are looking for candidates who bring strong motivation and curiosity and who are eager to grow technically and scientifically. The ideal candidate will have:
- A PhD in structural biology biophysics cell biology biochemistry or a related field
- Hands-on experience in cryo-electron microscopy for the determination of protein structures
- Experience in amyloid structure determination electron tomography and subtomogram averaging is an advantage but candidates currently training or transitioning into these areas are encouraged to apply
- Experience in specimen preparation for cryo-electron tomography including cryo-FIB/SEM lamella preparation and/or cryo-ultramicrotomy is a strong advantage; prior exposure or clear motivation to learn these techniques is also highly valued
- Basic programming or scripting skills (e.g. Python MATLAB Bash) are a plus
- Prior experience in amyloid biology protein aggregation or disease-related structural research are an advantage.
- Ability to work both independently and collaboratively in an interdisciplinary environment
- Adaptability and flexibility to thrive in a changing research environment and to adjust to evolving priorities
Our offer
- A vibrant world-class research environment operating at an international level
- Access to the resources of two host institutions:
- VIB an excellence-based research institute
- KU Leuven one of Europes leading research universities
- State of the art research facilities.
- A dedicated training program to broaden your expertise and enhance your skillset.
- A competitive compensation package based on expertise and experience
At SWITCH we have particular attention for the career development goals of our people and actively support the ambitions of our lab members in the lab and beyond. Information on SWITCH Lab alumni can be found here.
Starting Date: as soon as possible
How to apply
For more information contact Please complete the online application procedure ( and include a detailed CV including list of publications a motivation letter and the contact information of at least two referees.
Key Skills
- Virology
- Bioinformatics
- Genetics
- R
- Biochemistry
- Cell Biology
- Research Experience
- Spectroscopy
- Cell Culture
- Molecular Biology
- Microscopy
- Research Laboratory Experience
