Senior Scientist I, Lentiviral Engineering & In Vitro Assay Development

AbbVie is looking for a Senior Scientist to join our Genetic Medicine in vivo CAR-T group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to in vivo lentiviral delivery platforms. The successful candidate will drive scientific innovation identify and implement new methods and techniques and collaborate cross-functionally to advance our pipeline of novel in vivo CAR-T therapies.

Responsibilities:

• Lead research efforts design and execute in vitro studies (multi-color flow cytometry ELISA luciferase ddPCR etc.) and collaborate with in vivo pharmacology group for in vivo studies to advance lentiviral-based delivery platform development.
• Design and engineer lentiviral vectors and fusion protein receptors and oversee lentiviral production by leveraging internal capabilities and external CRO partnerships.
• Partner with cross-functional and therapeutic area teams to advance lentiviral-based in vivo CAR-T pipeline programs from early discovery through translational development.
• Uphold company culture teamwork and safety standards including appropriate handling of materials in a BSL-2 environment.
• Work independently with minimal supervision while maintaining a high level of productivity efficiency and scientific rigor.
• Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).
• Analyze and interpret multidisciplinary data to generate actionable conclusions identify key risks and guide future experimental directions.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications presentations and/or as a primary inventor of patent applications.
• Demonstrate a proactive solutions-oriented mindset and take ownership of additional responsibilities as needed.
• Mentor and support junior scientists within the team.

Qualifications :

• BS MS or PhD in immunology oncology cell biology molecular biology biochemistry or related field with typically 10 (BS) 8 (MS) or 0-3 (PhD) years of experience.
• Expertise in mammalian primary cell and cell line culture (primary T cells PBMCs whole blood suspension and adherent cell lines) multi-color flow cytometry (panel design acquisition and analysis) and immunological assays (e.g. ELISA Luminex cytotoxicity assays) is required.
• Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is highly preferred.
• Experience with lentiviral vector design production and analytical characterization (e.g. titering copy number analysis transduction efficiency assessment) is highly preferred.
• Experience in evaluating vector biodistribution transduction specificity or safety-related parameters is a plus.
• Experience in CAR-T cell therapy and/or in vivo targeted delivery is a plus.
• Proven ability to develop troubleshoot and refine assays to enhance sensitivity reproducibility and throughput.
• Highly self-motivated and capable of thriving in a fast-paced collaborative team environment.
• Strong written and verbal communication skills with experience contributing to technical reports publications or regulatory documentation.
• Detail-oriented with a passion for delivering high-quality results.

Why AbbVie
AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment opportunities for professional growth and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.

How to Apply:
If you are passionate about advancing in vivo CAR-T therapeutics and have a track record of success in cell and molecular biology we encourage you to apply! Please submit your resume outlining your relevant experience and why you would be a great fit for this position.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time