Medical Director, Kidney Disease, Early Clinical Development CVRM
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Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
The Medical Director will be focused on Kidney Disease and related conditions that impact kidney function. In this role you will have the opportunity to work at the forefront of early clinical and translational research within a multidisciplinary environment you will play a key role in progressing a rich and diverse pipeline of both small and large molecules in numerous active clinical programs.
Who We Are
In the Cardiovascular Renal & Metabolism (CVRM) Translational Medicine & Clinical Development (TSCD) department we are investigating the underlying factors contributing to CVRM disease progression using advanced scientific methodologies and data-driven drug this context we are evaluating a wide range of different drug modalities from our rich CVRM portfolio of compounds across kidney disease patient populations.
TSCD is where science meets clinical drug development with a focus upon delivering innovative early phase clinical studies and accelerating human target validation while collaborating closely with our late phase clinical development and regulatory colleagues who guide our pivotal phase 3 clinical studies.
What You Will Do
You will be responsible for managing and leading to early phase I-II global clinical trials and related clinical research projects for compounds that are targeting kidney disease as well as serving as an expert on the design conduct monitoring data interpretation and reporting of these studies. Additionally you will work on cross-functional teams within our TSCD group and across the broader global CVRM organization that are framing our strategies and development plans for compounds that are targeting cardiovascular diseases such as Heart Failure as well as major metabolic disorders such as Type 2 Diabetes Obesity and Metabolic Dysfunction-Associated Steatohepatitis given that these disorders intersect with chronic kidney disease and influence disease progression.
Responsibilities include:
- Lead early Phase III global trials in kidney disease: clinical strategy protocol design study conduct monitoring data interpretation and reporting ensuring scientific integrity patient safety and regulatory compliance.
- Provide clinical leadership to cross-functional teams; integrate preclinical insights (target selection pharmacology in vivo/in vitro data) into early clinical plans and seamless transitions to late phase development.
- Contribute to regulatory interactions and documentation (e.g. CTAs INDs safety updates annual reports).
- Advance the development and validation of nonclinical and surrogate endpoints (including imaging and biomarkers).
- Represent TSCD internally and externally through presentations publications and scientific forums; engage with external experts and translate insights into strategy and study design.
- Help evolve trial operations and site engagement to improve speed quality and inclusivity in early studies.
- Collaborate across CVRM on programs in heart failure type 2 diabetes obesity and metabolic dysfunction-associated steatohepatitis given their intersection with kidney disease.
Basic Qualifications:
- MD MBBS or MD/PhD with clinical or research expertise in in the treatment of kidney diseases.
- Minimum of 1 year of clinical research in academia and/or the pharmaceutical/biotechnology industry.
- Experience designing executing monitoring interpreting and overseeing safety in early clinical and translational trials preferred.
- Strong command of biomarkers surrogate endpoints and biostatistics supported by a robust publication record.
- Well developed interpersonal skills effective teamwork and the ability to engage stakeholders effectively across functions geographies and disciplines.
Why AstraZeneca
Here we need leadership at every level Physicians who not only have clinical and scientific expertise but also the ability to build a case engage multiple partners and communicate effectively with different audiences. With that kind of remit comes great responsibility. We truly believe that everyone contributes with an outstanding set of competence. Your curiosity and passion for personal development combined with support from colleagues mentors and leaders will ensure you maximize your skills abilities and contribution.
When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility.
Join us in our unique and bold world.
Date Posted
05-Sep-2025Closing Date
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Director
Key Skills
- EMR Systems
- Post Residency Experience
- Occupational Health Experience
- Clinical Research
- Managed Care
- Primary Care Experience
- Medical Management
- Utilization Management
- Clinical Development
- Clinical Trials
- Leadership Experience
- Medicare
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
