Senior Research Fellow (Medicinal Chemistry and Chemical Biology)

Join Our Team at the School of Biological Sciences Nanyang Technological University Singapore

The School of Biological Sciences (SBS) part of the College of Science at Nanyang Technological University was established in 2002 with a mission to advance excellence in biological and biomedical sciences. Our research spans diverse and impactful areas including infectious diseases immunology neurodegenerative disorders telomere biology and genome function. SBS is home to a vibrant international community of scientific leaders researchers and professionals dedicated to innovation discovery and education.

We are seeking a highly motivated Research Fellow to join our interdisciplinary research team focused on small-molecule drug discovery. Recently emerging chemically induced proximity (CIP) technologies have offered novel approaches to reprogramming the endogenous biological system to modulate disease-related proteins. This position will integrate medicinal chemistry and chemical biology approaches to discover and optimize novel therapeutics with future research focusing on developing next-generation proximity-inducing drugs.

Key Responsibilities:

• Propose hypothesis-driven target molecules based on emerging structure-activity relationships optimizing compounds so as to advance lead series for proximity inducing modalities (PIM).

• Solve complex synthesis problems using state-of-the-art methodology

• Collaborate closely with multidisciplinary team members to enhance research productivity and innovation.

• Maintain high level of expertise through familiarity with scientific literature.

• Use strong communication (both verbal and technical) and interpersonal skills to communicate objectives and results.

• Train and mentor graduate and undergraduate students.

Job Requirements:

• PhD in Synthetic Organic Chemistry Medicinal Chemistry or a closely related discipline.

• Strong hands-on experience in multi-step organic synthesis and compound design

• Demonstrated track record of research productivity (e.g. publications/patents)

• Proficiency in analytical methods (e.g. HPLC NMR LC-MS)

• Creative self-driven and solution-oriented mindset.

• Excellent communication and scientific writing skills.

• A creative self-driven mindset with excellent communication and writing skills

• Interest or experience in interdisciplinary research involving pharmacology biology or ADME/PK

• Ability to manage multiple projects in a fast-paced team-oriented environment

• Experience in targeted protein degradation and related modalities

• >4 years of postdoctoral experience is preferred

The College of Science seeks a diverse and inclusive workforce and is committed to equality of opportunity. We welcome applications from all and recruit on the basis of merit regardless of age race gender religion marital status and family responsibilities or disability.

We regret that only shortlisted candidates will be notified.