Principal Scientist, Cell Therapy Vector Engineering
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Job Location:
Spring House, PA - USA
Monthly Salary:
Not Disclosed
Posted on:
4 hours ago
Vacancies:
1 Vacancy
Job Summary
At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .
As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.
Job Function:
Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function:
Biotherapeutics R&DJob Category:
Scientific/TechnologyAll Job Posting Locations:
Spring House Pennsylvania United States of AmericaJob Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.
Learn more at are searching for the best talent for the best Principal Scientist Cell Therapy Vector Engineering to be in Spring House PA.
Purpose:
The Principal Scientist Vector Engineering position in the Cell Therapy Platform & Discovery group of Therapeutics Discovery offers an exciting opportunity to help develop novel Cell & Gene Therapies for unmet medical needs. We are investigating the use of engineered viral vectors for ex vivo and in vivo gene delivery to T cells to treat cancer. We are seeking a highly motivated scientist to own the design and screening of complex payloads to enable next-generation CAR-T cell products. Do you have industry experience building molecular engineering workflows and the ability to thrive in a cross-functional team Come join us in our mission to build the next generation of Cell & Gene Therapies for Oncology.
You will be responsible for:
Lead the design and experimental selection of genetic payloads with complex architectures (e.g. multiple expression cassettes and regulatory elements)
Build rigorous experimental workflows to establish design rules and methods for delivering complex payloads to primary T cells
Mentor junior colleagues to grow their experimental and analytical skills while establishing best practices within the team
Maintain detailed records and clearly communicate designs and results to enable efficient data-driven decisions in partnership with stakeholders
Contribute to a collaborative creative and rigorous culture of scientific discovery
Qualifications:
PhD in Biological Engineering Synthetic Biology Immunology Chemical Engineering Virology Biology or related field with at least 2 years of post-PhD industry experience; or BS/MS in the above fields with 6-8 years of related experience is required
Industry experience with evidence of scientific project leadership is strongly preferred
Experience designing and evaluating multicomponent genetic elements in primary cells is strongly preferred
Required skills: flow cytometry familiarity with molecular design software (Geneious Snapgene Benchling)
Desired skills include: primary T cell culture molecular biology assays (such as qPCR or ddPCR Western blot ELISA) high-throughput screening familiarity with DNA/RNA sequencing
Experience with lentiviral vector payload design is preferred
Strong critical scientific and strategic thinking skills are required
Strong communication and organizational skills with the ability to independently manage multiple projects in parallel are required
Demonstrated ability to work collaboratively in cross-functional teams is required
This role is may require up to 10% travel.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation please email the Employee Health Support Center () or contact AskGS to be directed to your accommodation resource.
Required Skills:
Preferred Skills:
Analytical Reasoning Biochemistry Biotechnology Chemistry Manufacturing and Control (CMC) Clinical Research and Regulations Clinical Trial Designs Coaching Critical Thinking Drug Discovery Development Emerging Technologies Molecular Diagnostics Organizing Pharmacovigilance Presentation Design Process Improvements Productivity Planning Scientific ResearchRequired Experience:
Staff IC
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
About Company
About Johnson & Johnson A t Johnson & Johnson, we believe good health is the foundation of vibrant lives, thriving communities and forward progress. That’s why for more than 130 years, we have aimed to keep people well at every age and every stage of life. Today, as the world’s larges ... View more
