Research Senior Associate, Inflammation Research

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Job Description

Pursuant to Section 20 C.F.R. 656.10 you are hereby notified that an application for Alien Employment Certification will be filed by Takeda Development Center Americas Inc. for the following job opportunity:

JOB LOCATION: Cambridge MA

POSITION: Research Senior Associate Inflammation Research

POSITION DESCRIPTION: Takeda Development Center Americas Inc. is seeking a Research Senior Associate Inflammation Research with the following duties: Design standardize and qualify assay platforms to interrogate TYK2-mediated JAK/STAT signaling across JAK-inhibitor programs; run cytokine-stimulated models (IL-12/IL-23/IFN) quantify target engagement and pathway inhibition (e.g. pSTAT) profile potency/selectivity and integrate literature-driven improvements to enhance sensitivity specificity and reproducibility; maintain ELN/SOP-compliant documentation and generate study reports suitable for regulatory filings and cross-asset comparability; Design and qualify transcriptional analysis workflows in primary cells whole blood and hematopoietic/immune cell matrix by defining stimulation/compound paradigms performing RNA extraction outsourcing RNA-seq and managing data transfer for analysis/interpretation; Establish and govern PBMC biobanking by optimizing isolation methods streamlining workflows to improve yield/viability/cycle time maintaining inventory and capturing ELN- and SOP-compliant records; Optimize lab workflows through Global Compound Management and Laboratory Automation (GCM) coordination SOP/plate-template standardization liquid-handling automation and GENI tracking to increase throughput and reduce error; collaborate with DD&T team to streamline data flow and tool integration; independently troubleshoot protocols instrumentation (e.g. plate readers cytometers) and analytical software and implement corrective actions to resolve complex technical issues; Collaborate with Statistics/Quantitative Sciences group to analyze/interpret data and generate robust reports to support regulatory filings; Establish standardize and enforce Takeda-standard laboratory safety protocols quality control measures and standard operating procedure (SOP) workflows to ensure company and regulatory compliance; Up to 20% remote work allowed.

The estimated salary range reflects an anticipated range for this position. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical dental vision insurance a 401(k) plan and company match short-term and long-term disability coverage basic life insurance a tuition reimbursement program paid volunteer time off company holidays and well-being benefits among others. U.S. based employees are also eligible to receive per calendar year up to 80 hours of sick time and new hires are eligible to accrue up to 120 hours of paid vacation.

REQUIREMENTS: Masters degree in Immunology Molecular Biology Biomedical Engineering or related field plus 2 years of related experience. Prior experience must include: Scientific knowledge of immunology cell and molecular biology autoimmunity and inflammation; Perform advanced cellular and molecular biology techniques including cell culture primary cell culture/isolation cell imaging (eg. EVOS 500) ELISA Ella MSD/Luminex Western blot qPCR RNA extraction flow cytometry (conventional and spectral) MACS liquid handler (VIAFLO Assist Plus) high-throughput automation system (Kingfisher); Demonstrate proficiency in GraphPad Prism FlowJo Benchling SnapGene to analyze quantitative and qualitative experimental data to generate valid conclusions and related statistical/data visualization tools; Develop optimize and analyze immune-function assays (in vitro/ex vivo) to produce phenotypic/functional readouts in support of the development and evaluation of small-molecule biologic and nucleic-acid therapeutics; Semi-automate workflows with liquid handlers to optimize SOPs for standardization reproducibility and throughput; Leverage technical experimental expertise to improve the workflow and to mitigate problems related to experimental protocols laboratory instrumentation and analytical software and implement solutions to restore functionality and data integrity; Communicate results by presenting data at lab/department meetings and cross-functional reviews and by authoring ELN entries technical reports slide decks and long-form documents (e.g. thesis/manuscript sections) for project stakeholders; Succeed within cross-functional teams including medicinal chemistry bioinformatics and translational research to integrate diverse datasets into cohesive project strategies; Deliver consistent performance in laboratory safety standards quality control procedures and regulatory-compliant documentation for all experiments including accurate and timely recordkeeping in Electronic Lab Notebooks (ELNs) to ensure data integrity and audit readiness.

Full time. $99500.00 - $170600.00 per year

Qualified applicants can apply at . Please reference job #R0173670. EOE

Any individual may provide documentary evidence bearing on this application with information on available workers and information on wages and working conditions to the Certifying Officer U.S. Department of Labor Employment and Training Administration Office of Foreign Labor Certification 200 Constitution Avenue NW Room N-5311 Washington DC 20210.

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