Postdoctoral Fellow
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Job Location:
Boca Raton, FL - USA
Monthly Salary:
Not Disclosed
Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
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Position Summary:
The Roche Research Group at Florida Atlantic University is seeking a highly motivatedPostdoctoral Fellowto join an interdisciplinary research program focused on developing next-generation peptide therapeutics targeting proteinprotein interactions (PPIs) in inflammatory disease.
This Leo Foundationsupported project leverages theADAPT platform a novel technology that converts antibody CDR-H3 loops into β-hairpin peptide mimetics with antibody-like specificity and improved pharmacokinetic properties. The primary biological focus is the inhibition ofIL-17 and IL-23 signaling pathwaysrelevant to psoriasis (I&I).
Responsibilities:
. Design synthesize and characterize CDR-H3mimetic β-hairpin peptides using solid-phase peptide synthesis (SPPS)
Develop and screen non-covalent and covalent peptide libraries
Perform peptide folding and stability analyses (CD spectroscopy VT-CD)
Conduct structural studies by NMR spectroscopy
Collaborate on biochemical cellular and in vivo validation studies (ELISA keratinocyte assays murine psoriasis models)
Analyze and integrate chemical biophysical and biological data for publication
Contribute to manuscripts grant reports and collaborative discussions
The successful candidate will work in a well-equipped laboratory environment and interact closely with collaborators at the Miller School of Medicine at the University of Miami the University of Colorado and the UF-Scripps Institute for biological and pharmacokinetic studies.
Minimum Qualifications:
Ph.D. in Chemistry Medicinal Chemistry Chemical Biology or a closely related fieldStrong background in synthetic organic or peptide chemistry
Experience with SPPS and peptide purification (HPLC LC-MS)
Ability to work independently while contributing to a collaborative research team
Preferred Qualifications
Experience with peptide secondary structure analysis (CD NMR)
Familiarity with covalent inhibitors or proteinprotein interaction modulators
Interest in translational research and drug discovery
Salary:
$62000.00College or Department:
Roche Research GroupLocation:
Boca RatonWork Days and Hours:
N/AApplication Deadline:
Special Instructions to Applicant:
This position is open until filled and may close without prior notice.This position is subject to funding.
All applicants must apply electronically to the currently posted position on the Office of Human Resources job website ( by completing the required employment application for this recruitment and submitting the related documents.
Required Documents:
FAUs Career Page permits the attachment of required/requested documentation.
PLEASE NOTE: A maximum of five (5) documents may be attached to your application. If more than five (5) documents are required for submission please combine additional documents into a single attachment to not exceed the maximum permitted.
The site permits the attachment of required/requested documentation. Candidates wishing full consideration are to provide the following:
. CV
. Brief statement of research interests
. Contact information for 23 references
Transcripts:
Final candidate will be required to have official sealed transcripts and original NACES evaluation if applicable sent from their educational institution to Human Resources prior to the start of employment.
Background Screening:
Selected candidates must successfully complete and pass all employment screenings prior to the start of employment. Employment screenings may include a criminal background check (level I and level II) motor vehicle check credit check reference checks alcohol and drug screening check.
Accommodations:
Individuals requiring accommodation please call . 711
Key Skills
- Virology
- Bioinformatics
- Genetics
- R
- Biochemistry
- Cell Biology
- Research Experience
- Spectroscopy
- Cell Culture
- Molecular Biology
- Microscopy
- Research Laboratory Experience
About Company
Florida Atlantic University (FAU) is a student-centered public research university committed to empowering students who want to make a difference.
