Principal Scientist, Protein Therapeutics – Mammalian Expression & Cell Line Engineering

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Job Description

Join Amgens Mission of Serving Patients

At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.

Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Scientist Protein Therapeutics Mammalian Expression & Cell Line Engineering

What you will do

Lets do this. Lets change the this vital role you will join the Protein Therapeutics organization within Research. This role will provide scientific and technical leadership in mammalian expression and cell line engineering to support the discovery and optimization of large-molecule therapeutics including antibodies bispecific and next-generation protein modalities.

This is a senior individual contributor role with no direct reports.

The successful candidate will be a recognized technical expert and scientific leader who drives innovation in mammalian expression systems cell line engineering strategies and enabling technologies with a strong emphasis on data-driven decision making and automation-enabled workflows.

Key Responsibilities

Scientific Leadership and Innovation

• Serve as a scientific leader and subject matter expert in mammalian expression and cell line engineering influencing technical strategy across protein therapeutic programs.
• Champion innovative approaches in mammalian expression host cell engineering and expression construct design to improve productivity quality and speed.
• Identify develop and implement new technologies platforms and automation solutions that enhance robustness scalability and throughput of expression workflows.

Technical Execution Data and Problem Solving

• Execute wet laboratory experiments to express therapeutic proteins in mammalian cells both in high throughput bench-scale productions and medium-scale shake flask productions.
• Solve high-impact technically complex problems related to expression post-translational modification stability and developability.
• Apply data-driven approaches to optimize expression systems and processes.
• Partner closely with informatics and automation teams to enable high-throughput reproducible and scalable workflows.

Collaboration and Influence

• Work effectively across functions including protein engineering molecular biology analytics process development and data sciences to advance programs.
• Provide technical guidance and mentorship to scientists within and outside the immediate group without direct line management responsibility.
• Represent the mammalian expression and cell engineering function on project teams governance forums and internal scientific reviews.

External Awareness and Scientific Impact

• Maintain deep awareness of external scientific and technological advances in mammalian expression cell engineering automation and data-enabled biology.
• Contribute to Amgens scientific reputation through publications patents presentations and participation in internal and external scientific forums.
• Evaluate and influence external collaborations technologies and partnering opportunities as needed.

What we expect of you

We are all different yet we all use our outstanding contributions to serve patients. The Professional we seek is an agile leader with these qualifications.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD and relevant scientific experience and 2 years of scientific experience OR
• Masters degree and 5 years of scientific experience OR
• Bachelors degree and 7 years of scientific experience.

Preferred Qualifications

• Ph.D. with significant postdoctoral and/or industry experience in biotech or pharma with a strong focus on mammalian expression and cell line engineering.
• Deep expertise in mammalian cell biology expression construct design host cell engineering and expression strategies for a broad range of protein therapeutics.
• Demonstrated experience implementing data-rich automated and high-throughput expression or cell engineering workflows.
• Strong understanding of how protein sequence structure and biophysical properties impact expression quality attributes and downstream developability.
• Proven record of independent scientific achievement evidenced by high-impact publications patents and/or implemented technologies.
• Excellent written and verbal communication skills with the ability to influence without authority and operate effectively in a highly matrixed environment.

What you can expect of us

As we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.

In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:

A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accounts

A discretionary annual bonus program or for field sales representatives a sales-based incentive plan

Stock-based long-term incentives

Award-winning time-off plans

Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

In any materials you submit you may redact or remove age-identifying information such as age date of birth or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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