ML Research Scientist De Novo Design

San Francisco, CA - USA

Monthly Salary: $ 235 - 270

Posted on: 11 hours ago

Vacancies: 1 Vacancy

Job Summary

Merge Labs is a frontier research lab with the mission of bridging biological and artificial intelligence to maximize human ability agency and experience. Were pursuing this goal by developing fundamentally new approaches to brain-computer interfaces that interact with the brain at high bandwidth integrate with advanced AI and are ultimately safe and accessible for anyone to use.

About the team:

Merge is building the next generation of brain-computer interfaces by combining recent advances in synthetic biology neuroscience AI and non-invasive imaging. To support this mission we are building a cross-functional data-science group which sits at the intersection of computational modeling neuroscience and biomolecular engineering. This group collaborates extensively with wet-lab scientists automation engineers and data engineers to create ML frameworks that accelerate molecule discovery and device optimization.

About the role:

Were hiring a Senior / Principal ML Scientist to design and scale de novo design frameworks that guide molecular engineering campaigns through iterative designbuildtestlearn (DBTL) cycles. Starting from a blank slate youll first architect the companys closed-loop optimization backbonebuilding the data and modeling foundations that connect experiments to these ML frameworks. Over time youll help translate these prototypes into production pipelines that measurably improve experimental throughput and discovery success across multiple biomolecular and neuroengineering verticals.

In this role you will:

Build the scientific and engineering scaffolding in collaboration with data-engineering & MLOps for de novo design and closed-loop optimization including data ingestion ML modeling and library design.
Collaborate with wet-lab scientists to define tractable optimization objectives and encode domain specific priors and constraints.
Prototype de novo design frameworks using internal and public datasets; benchmark and validate model performance.
Integrate ML models with experimental data streams and serve to non-domain experts for model democratization.
Extend ML frameworks to handle multi-objective or constrained optimization problems.
Stay up-to-date with the latest research in de novo design and prototype novel algorithms that can be deployed to improve the companys discovery or development workflows.
Contribute to the long-term research roadmap and serve as a thought-leader for scientists.

You might thrive in this role if you have:

Strong grounding in SSMs LLMs SE(3)-equivariance Flow-matching.
Working knowledge of transfer-learning strategies.
Proficiency in Python / PyTorch / Jax and comfort writing clean reproducible production grade code.
Experience bridging machine learning and experimental science working with sparse noisy and or high-cost data.
A collaborative systems-level mindset.
Nice to have: familiarity with neuroscience.

If youre excited about this role but dont meet every qualification please apply. As we build were hiring for complementary strengths to form a high-impact team.

Merge Labs does not discriminate on the basis of race color religion national origin age sex sexual orientation gender gender identity gender expression marital status physical or mental disability medical condition genetic information family status ancestry citizenship U.S. military (state and federal) and veteran status or any other legally protected status. It is our intention that all applicants be given equal opportunity and that selection decisions are based on job related factors. We are an equal opportunity employer.

Pursuant to the San Francisco Fair Chance Ordinance we will consider for employment qualified applicants with arrest and conviction records.

We are committed to providing reasonable accommodations to applicants with disabilities and requests can be made by emailing

Required Experience: