Sr. Scientist, Molecular Discovery

Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our companys success is backed by ethical integrity forward momentum and an inspiring mission to achieve new milestones in global healthcare.

We are on a quest for cures and are committed to be the worlds premier most research-intensive biopharmaceutical company. Today were doubling down on this goal to take our companys leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Discovery Biologics in Boston MA is seeking a Senior Scientist to join our Molecular Interactions group and expand our capabilities to engineer and characterize novel biologics and cell therapies. The group is responsible for developing fit-for-purpose binding assays with an array of technologies to characterize a portfolio of biologics including monoclonal antibodies bi/multi-specifics Fc-fusion proteins and other novel protein therapeutics. The Molecular Interactions group is part of the Discovery Biologics organization which uses machine learning advanced automation ultra-high throughput in vitro and in vivo technologies and state-of-the-art characterization techniques to discover and engineer biologics.

In this role the successful candidate will directly contribute to the invention of novel biologics and will be responsible for the molecular interaction analysis of therapeutic candidates through state-of-the-art technologies including surface plasmon resonance (SPR) biolayer interferometry (BLI) kinetic-exclusion assay (KinExA). Using their deep expertise in molecular interactions method development high throughput execution and the application of new technologies they will enable the discovery and engineering of biologics. As part of project teams they will collaborate across groups to solve complex problems in disease biology and drug discovery. They will attend scientific conferences contribute to publications and help to set the group strategy. The successful candidate will join a group of innovative scientists and engineers that are driving the next revolution in biologics discovery and engineering.

We recognize that in our team is our strength and are dedicated to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a group of scientists to drive our core mission.

Responsibilities:

• In support of program priorities deliver detailed molecular interaction characterization data and analysis of therapeutic candidates from optimized methods using state-of-the-art technologies including SPR (Carterra LSA and Biacore) BLI (Octet) and KinExA

• Present research findings at group meetings project meetings and at external meetings

• Contribute to program strategy as a characterization representative on project teams

• Collaborate with team members to expand characterization and developability workflows for analysis and optimization of lead biologic molecules

• Actively develop talent strategically maximize to complement and strengthen our team

• Foster a high-performance culture of collaboration engagement self-accountability and inclusion

• Contribute to and lead the authoring of patents and external publications

Qualifications and Experience:

• PhD in Biochemistry Biomedical Sciences/Bioengineering or a related discipline with 0-3 years of relevant industry experience or MS degree with >5 years of relevant industry experience

• Broad experience in molecular interaction and biophysical characterization techniques

• Expertise in molecular interaction/analytical method development high throughput execution and the application of new technologies

Required skills:

• Deep expertise in method design and characterization of biotherapeutic protein:protein interactions using relevant technologies (SPR BLI KinExA) to assess kinetics and affinity specificity and epitope

• Hands-on experience with Carterra LSA to interrogate large data sets for both kinetic/affinity and epitope binning analysis is required

• Experience delivering comprehensive characterization analysis incorporating the full spectrum of characterization data (molecular interactions analytical and functional/cellular assay) to drive the selection and progression of therapeutic leads in the discovery pipeline

• Demonstrated ability to work in a collaborative multi-disciplinary team environment

• Excellent communication and organizational skills

Preferred skills

• Experience with on-cell affinity analysis using techniques including KinExA Mesoscale ELISA assays and flow-cytometry (FACS)

• Experience with any of the following analytical techniques including enzyme-linked immunosorbent assay (ELISA) isothermal calorimetry (ITC) Microscale Thermophoresis (MST) light scattering (SEC-MALS DLS) thermal stability (DSF/DSC) and mass photometry

• Experience integrating lab automation to enable instrument setup and characterization workflows (Tecan Biomek Hamilton or similar)

• Hands-on experience with protein conjugation techniques

• Experience developing microfluidics lab-on-a-chip or flow-based research

• Fluency in a modern programming language such as C Python or similar

Required Skills:

Preferred Skills:

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Our company is committed to inclusion ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:

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We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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