Two Postdoctoral Researchers in Mathematical and Computational Oncology for Personalized Breast Cancer Treatment
Share
Job Location:
Monthly Salary:
Posted on:
13 hours ago
Vacancies:
1 Vacancy
Job Summary
About the position
We are seeking two ambitious Postdoctoral Researchersto join the Köhn-Luque group at the Oslo University Hospital. These 3-year positions are part of a high-impact project funded by the Norwegian Cancer Society titled Precision biomarkers for CDK4/6 inhibition in breast cancer. Start date: Negotiable (immediate preference).
About the project: The core objective is to develop validate and initiate clinical translation of precision biomarkers for CDK4/6 inhibitors in breast cancer. Following previous work from Köhn-Luques group (Schmiester et al. Clin Cancer Res 2024; Lai et al Cancer Res 2019) we plan to integreate extensive preclinical and clinical data with mechanistic mathematical modeling and machine learning to deliver personalized treatment recommendations.
The candidates will join a multidisciplinary research team at the Department of Medical Genetics at the Oslo University addition they will collaborate with researchers and clinicians in different institutions in Norway and abroad including Integreat: The Norwegian Centre for Knowledge-driven Machine Learning the Akerhus University Hospital northeast of Oslo and the Clinic Hospital in Barcelona. The candidates will also be involved in a SPARK Norway innovation project that is exploring the commercial potential of mathematical and computational biomarkers.
The Department of Medical Genetics at Oslo University Hospital is Norways largest medical genetics department with over 200 employees. The department is responsible for diagnostics of rare and inherited diseases and runs a national research infrastructure for high-throughput DNA sequencing at the Norwegian Consortium for Sequencing and Personalized Medicine. The research section in the department has several research groups working in various fields of medical genetics including breast cancer the genetics of autoimmune neurological cardiovascular and psychiatric disorders epigenetics causes of disease as well as groups focusing on mathematical modeling artificial intelligence and bioinformatics.
Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions and we encourage all qualified candidates regardless of background to apply!
Key information
Job descriptions
Position 1: Mathematical Modeler in Oncology.
The focus is on modeling and simulating underlying biological mechanisms of drug response. Main tasks include but are not limited to:
- Model development: Construct and refine mechanistic mathematical models (predominantly systems of ODEs) that describe the pharmacodynamics of CDK4/6 inhibitors and interaction with other targeted therapies.
- Data management: Curate analyze and maintain molecular and clinical datasets
- Data integration: Perform sophisticated calibration and parameter estimation using high-dimensional longitudinal data including transcriptomics and proteomics.
- Predictive Simulations: Use validated models to perform in silico trials identifying optimal dosing schedules and resistance-evading combinations.
Position 2: Machine Learning Researcher in Oncology.
The focus is on integrating machine learning and mechanistic modeling to discover underlying biological mechanisms from data. Main tasks include but are not limited to:
- Model learning evaluation: Conduct rigorous evaluations of model learning approaches for noisy and high-dimensional data.
- Hybrid frameworks: Extend hybrid machine learning frameworks (e.g. Universal Differential Equations Universal Physics-Informed Neural Networks) to represent unknown biological pharmacodynamics from multi-omics data.
- Interpretability: Discover parsimonious mathematical expressions from omics data using symbolic regression specifically to understand how interpretable biomarkers enter and govern the functional forms of mechanistic models.
- Benchmarking: Establish rigorous pipelines to compare the predictive performance of hybrid and symbolic models.
The physical working location will be at the Department of Medical Genetics Section for Research and Development. From January 2027 the Department will move to the Life Science building providing the applicants the exciting opportunity to work in Norways largest and most modern research building.
Qualifications
Education: A PhD in Mathematics Statistics Physics Computer Science Computational Biology or a related quantitative field. The PhD degree must be obtained by the start date.
Computational expertise: Extensive experience in scientific computing and software development. The candidate must demonstrate the ability to develop and maintain code (Python Julia R or C)
Mathematical Modeling (Position 1): Deep theoretical and practical expertise in dynamical systems numerical analysis of ODEs/PDEs statistical inference parameter estimation and optimization for systems biology modeling.
Machine Learning (Position 2): Strong theoretical and practical experience in machine learning specifically in dynamical model learning methods (e.g. neural differential equations symbolic regression).
Experience in the following topics will be considered an advantage:
- Experience with transcriptomics and proteomics data.
- Experience working on servers and/or in a HPC environment.
Personal qualities
- We are looking for a researcher who is highly motivated well-organized and dynamic with a high level of independence and creative thinking.
- Ability to present and execute novel ideas in method development data analysis and interpretation.
- Team player who can work independently in a multidisciplinary and international team.
- Excellent oral and written English communication skills.
- Proactive flexible and problem-solving attitude.
- Experience in working with deadlines and being involved in multiple projects.
We offer
- A 3-year full-time contract in a world-class research environment with possibility for extension depending on the availability of funding.
- A 6 months trial period will be applied.
- Salary in agreement with the current collective agreement and qualifications/experience.
- Favorable pension arrangements.
- A stimulating (international multidisciplinary) research environment where quality professionalism and team spirit are encouraged.
- A productive and motivating research environment.
- Attractive welfare arrangements.
How to apply and information about what the application must include:
- Applications only through Webcruiter are accepted.
- The application letter including a summary of scientific work and interest. Please indicate you fit in Position 1 Position 2 or both.
- CV summarizing education positions and other qualifying activity.
- Copies of educational certificates with grades.
- Names email and telephone number of 3 referees (describe relation to applicant).
- A complete list of publications highlighting the candidates role in main publications relevant to the position.
Links
- The Department of Medical Genetics: Consortium for Sequencing and Personalized Medicine: Norway: Science building: KirkeveienOslo Norway
Contacts
Key Skills
- Hospital Experience
- Acute Care
- Basic Life Support
- ICU Experience
- Infusion Experience
- Triage
- TFS
- Conflict Management
- Nursing
- Critical Care Experience
- Epic
- Medication Administration
About Company
Oslo University Hospital is a highly specialized hospital in charge of extensive regional and local hospital assignments. As Scandinavia’s largest hospital, we carry out more than 1.2 million patient treatments each year. The hospital has a nationwide responsibility for a number of na ... View more
