Senior Scientist I, Clinical Biomarker Development

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionariesin a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The Senior Scientist I in Clinical Biomarker Development team within the Translational Medicine will play a key role in the design execution and interpretation of clinical biomarker strategies across Revolution Medicines oncology pipeline. You will:

• Design and execute clinical biomarker strategies to support early response monitoring patient stratification and understanding resistance mechanisms.

• Support biomarker implementation for early- and late-stage oncology clinical trials.

• Oversee biomarker assay development qualification and sample analysis in collaboration with internal teams and external CROs.

• Analyze and interpret biomarker data in the context of clinical outcomes and present results to cross-functional teams.

• Contribute to clinical protocols study reports and regulatory documents (e.g. INDs IBs CSRs).

• Translate preclinical findings into clinically actionable biomarker hypotheses.

• Stay current with emerging biomarker technologies and trends in precision oncology.

Required Skills Experience and Education:

• PhD in a relevant scientific discipline with 3 years of relevant industry experience in clinical biomarkers translational medicine or related roles.

• Experience supporting oncology clinical trials with biomarker components.

• Familiarity with biomarker platforms such as genomic/molecular and proteomic assays.

• Experience working with CROs and managing external vendors.

• Strong scientific communication skills and ability to work cross-functionally.

Preferred Skills:

• Experience with targeted oncology therapies or RAS/MAPK pathway biology.

• Biological understanding of pancreatic non small cell lung and/or colorectal cancers is preferred.

• Familiarity with analytical software for data anlaysis and interpretation.

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