Postdoc Therapeutic Epigenetic Editing in vivo

Your group

Hackett

Your supervisor

Jamie Hackett

Your role

You will lead an in vivo epigenome editing programme focused on the delivery of epigenetic editors in mouse liver to modulate target gene expression. Based at EMBL and working jointly with biotech partners you will be responsible for the implementation of in vivo workflows including mouse dosing with AAV and/or LNP coordinated tissue collection and downstream molecular and genomics analyses. The goal is to engineer therapeutic changes in target gene expression.

The role offers a unique opportunity to work at the academicindustry interface providing exposure to translational research biotech operating models and clinically oriented decision-making. The position operates to experimental plans and milestones and is thus well suited to candidates who value structured high-quality experimental execution. There is access to state-of-the-art technologies and full mouse husbandry support as well as training in mouse biology. There is also the oppurtunity to lead and supervise a small team of researchers to achieve the experimental goals. This position is thus an excellent bridge for highly motivated scientists seeking to build future leadership careers in translational biology or biotechnology.

You have

• PhD in Gene Therapy Epi(genomics) or a related field and proven research experience in a relevant field.

• Experience with mouse biology including working with AAV and/or LNP delivery

• Strong experience of core molecular biology techniques (qRT-PCR ChIP cloning etc) and analysis.

• Motivation to work in an international team bridging academia and biotech to develop technologies towards clinical translation.

• Good communication and interpersonal skills

• Fluency in English is essential

You may also have

• Experience with liver biology and diseases.

• A working understanding or experience with CRISPR design and implementation

• Ability to analyse genomics data including RNA-seq or ChIP-seq

Contract length:

2 years with potential to be extendable upto 5 years.

Salary:

At least 3.228 EURO/month after tax

Professional development support

The EMBL Fellows Career Service provides support and guidance to predoctoral and postdoctoral fellows across all six EMBLs sites.

Working with a dedicated Careers Advisor this invaluable service will help you to take informed decisions about your career planning both in the short and longer term. Whether your main interest is pursuing a career path in academia exploring opportunities in industry or exploring an independent venture the EMBL Fellows Career Service with provide you with a portfolio of activities and resources to help you.

To find out more please visit - EMBL-fellows-career-service

Why join us

Enjoy lots of employee benefits:

• Financial incentives:Monthly family and child allowances generous stipend reviewed yearly pension scheme death benefit and unemployment insurances

• Flexible working arrangements including hybrid working patterns

• Private medical insurancefor you and your immediate family

• Generous time off:30 days annual leave per year in addition to public holidays

• Campus life:Free shuttle bus (Heidelberg) on-site library subsidised on-site cafeteria casual dress code extensive sports and social club activities (on campus and remotely)

• Family benefits: Kindergarten (Heidelberg) 10 days of child sick leave paid maternity & parental leave holiday clubs on campus and monthly family and child allowances
  

What else you need to know

• International applicants: We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants.

• Diversity and inclusion: At EMBL we believe that diverse teams drive innovation and scientific excellence. We encourage applications from candidates of all genders identities nationalities and/or any other diverse backgrounds.

• Job location: All our fellowships are based on-site (for at least part of each week). If you are living overseas you will receive a generous relocation package to support you.

• EMBL is a signatory of DORA. Find out how we apply DORA principles to our recruitment and performance assessment processes here

• How to apply: To apply please submit a cover letter and a CV through our online system. Applications will close at 23:59 CET on the date shown below. We aim to provide a response within two weeks after the closing date.

Closing Date