Post Doctorant Pharmacologie (organoïde et in vivo)

About Ipsen:

Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology Rare Disease and Neuroscience. Supported by nearly 100 years of development experience with global hubs in the U.S. France and the U.K we tackle areas of high unmet medical need through research and innovation.

Our passionate teams in more than 40 countries are focused on what matters and endeavor every day to bring medicines to patients in 88 countries. We build a workplace that champions human-centric leadership and fosters a culture of collaboration excellence and impact. At Ipsen every individual is empowered to be their true selves grow and thrive alongside the companys success. Join us on our journey towards sustainable growth creating real impact on patients and society!

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WHAT - Summary & Purpose of the Position

This postdoctoral position aims to design develop and evaluate disease-relevant in vitro 3D models (organoids/spheroids) to strengthen predictive pharmacology and biomarker translation for clinical success. The role will benchmark new approach methodologies (NAMs) against existing 2D and in vivo models consolidate data across CRO partners and bridge findings with in vivo PDX/mini-PDX studies to assess translational value.

The postdoc will operate across Paris HQ and Dreux labs and collaborate with selected CROs to ensure robust methodology reproducibility and alignment with FDA/EMA guidance on alternative methods. Expected impact includes increased relevance of preclinical models reduced animal use where scientifically justified and improved decision-making for Ipsens pipeline.

WHAT - Main Responsibilities & Technical Competencies

• Main Responsibilities

Innovate with 3D Models:

• Develop and characterize organoid and spheroid models to better predict drug response and biomarker behavior either with external collaboration with CROs or in our internal lab facilities in Dreux

Bridge In Vitro and In Vivo:

• Plan and conduct in vivo studies in CROs (PDX mini-PDX) to validate translational potential and establish correlations with 3D models.

Drive Scientific Excellence:

• Design protocols ensure data quality and analysis.
• Document experimental protocols and results in compliance with Ipsen standards and quality; Record data in ELNs and write reports
• Ensure compliance with ethical and regulatory standards and deliver robust reproducible data packages.
• Stay up to date with emerging technologies and scientific advances in NAMs.

Collaborate and Communicate:

• Work closely with CROs internal teams and academic partners. Present findings and strategic recommendations to Ipsens Translational Sciences team.
• Collaborate with translational teams to integrate findings into clinical biomarker strategies.
• Collaborate with in vitro pharmacology and clinical biomarker teams .
• Communicate results effectively in multidisciplinary project meetings and external conferences
• Participate to external communication and/or publication (if applicable)

• Technical Competencies

• Hands-on experience with 3D models (organoids spheroids) and in vivo models (oncology PDX).
• Strong technical skills: imaging qPCR IHC multiplex assays PK/PD analysis.
• Knowledge of NAMs and regulatory guidelines (FDA/EMA).
• Excellent communication skills and fluency in English.
• Familiarity with translational research and biomarker development.

• Behavioural Competencies

• Scientific curiosity and innovation ability to propose and implement novel approaches.
• Collaboration and communication team player working effectively in cross-functional teams.
• Problem-solving and adaptability manage complex experimental challenges.
• Accountability and rigor ensure high-quality reproducible research

• Environment Health and Safety (EHS)

• Comply with applicable EHS regulations and procedures
• Contribute to the sites EHS performance by reporting risks malfunctions or improvements
• Participate in mandatory EHS training

HOW - Behavioural Competencies Required

Collaboration e.g. working closely with CROs and internal teams to align project goals.

Accountability taking ownership of experimental design and data integrity.

Agility adapting to new technologies such as organ-on-chip platforms.

Innovation proposing novel approaches for predictive pharmacology.

Integrity ensuring compliance with ethical and regulatory standards.

HOW - Knowledge & Experience

Knowledge & Experience (essential):

• Experience in designing and performing in vitro and ex vivo models 3D models.
• Expertise in cell culture methods cellular and molecular biology and biochemistry.
• Experience in designing and piloting in vivo studies
• Able to develop new techniques and methodologies tailored to project needs
• Exposure to translational activities linking preclinical findings to clinical applications.
• Good organizational and prioritization skills.
• Ability to work as part of a team in a multidisciplinary environment in a matrix environment
• Strong problem-solving and critical thinking abilities.
• Excellent communication and collaboration skills (written and oral).
• Travel to Dreux as required for lab experiments projects and interaction with TS team members.

Knowledge & Experience (preferred):

• Familiarity with new approaches for 3R and clinical trial support.

Education / Certifications (essential):

• Ph.D. in Pharmacology Oncology or related field.

Language(s) (essential):

• French fluent
• Fluent English