Senior Scientist, Cell Therapy

Gaithersburg, MD - USA

Monthly Salary: Not Disclosed

Posted on: Yesterday

Vacancies: 1 Vacancy

Job Summary

We are seeking a highly-motivated and independent Senior Scientist with expertise in Cellular Therapy Immunology and/ or Immuno-Oncology and demonstrated experience in Computational Biology to join our rapidly growing Cell Therapy this role you will make use of your in vitro experience in T cell immunology and your knowledge of computational models and large-scale -omic datasets to contribute to the advancement of innovative Cell Therapy products by designing and conducting laboratory experiments developing methodology and generating and interpreting scientific data in a highly collaborative environment.

Accountabilities

Conducts routine drug discovery research experiments by applying the techniques of molecular and cellular biology communicates the results to team members and is involved in the interpretation of data
Conducts hands-on in vitro research and contributes to the plans and designs of in vitro and in vivo studies
Supports a team and works collaboratively in a matrix environment
Assesses and reports data with little or no guidance in a clear and concise manner while developing an understanding of its implications within the overall context of drug discovery
Uses their knowledge of coding data processing and AI platforms/ machine learning to extract knowledge and insights from structured and unstructured data sources relevant to the development of new therapies
Provides technical instruction to the team and allocates administrative work where possible
Communicates and shares information between distinct projects within the bioscience function and across other functions as required
Ensures own work and work of peers is compliant with Safety Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Essential

Senior Scientist: PhD in a relevant discipline (e.g. Biology Immunology Immuno-Oncology Biomedical Engineering) with a minimum of 2 years of demonstrated experience in Computational Biology Data Science and/ or Computer Science
Extensive in vitro skillset with a well-developed understanding of molecular and cellular biology immunological assays and cell transfection/ transduction and advanced cell culture techniques
Ability to design execute and troubleshoot experiments and to review analyse and interpret results
Proficiency in Python and/or R
Expertise in -omics technologies and ability to process large-scale biological datasets (e.g. single-cell/spatial transcriptomics in-house proprietary data sources such as in vitro or in vivo data)
Understanding of AI and predictive modelling tools

Desirable

Experience with genome editing technologies (CRISPR/ Cas9 base-editing transposons etc.)
Hands-on experience in T-cell functional characterization assays such as in vitro cytotoxicity proliferation cytokine measurement and multi-parameter flow cytometry
Basic experience developing cellular therapies including CAR-T/ CAR-NK TCR-T and/ or TIL therapies
Background in drug discovery and development in the pharmaceutical industry
Prior experience in UNIX-based systems and high-performance computing (e.g. SLURM) with applications to large-scale data analysis and management
Experience developing and implementing machine learning models
In vivo skillset including animal handling mouse tumour models standard routes of dosing and engraftment and tissue processing

Date Posted

04-Feb-2026

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.

Required Experience:

Senior IC

Accountabilities

Conducts routine drug discovery research experiments by applying the techniques of molecular and cellular biology communicates the results to team members and is involved in the interpretation of data
Conducts hands-on in vitro research and contributes to the plans and designs of in vitro and in vivo studies
Supports a team and works collaboratively in a matrix environment
Assesses and reports data with little or no guidance in a clear and concise manner while developing an understanding of its implications within the overall context of drug discovery
Uses their knowledge of coding data processing and AI platforms/ machine learning to extract knowledge and insights from structured and unstructured data sources relevant to the development of new therapies
Provides technical instruction to the team and allocates administrative work where possible
Communicates and shares information between distinct projects within the bioscience function and across other functions as required
Ensures own work and work of peers is compliant with Safety Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Essential

Senior Scientist: PhD in a relevant discipline (e.g. Biology Immunology Immuno-Oncology Biomedical Engineering) with a minimum of 2 years of demonstrated experience in Computational Biology Data Science and/ or Computer Science
Extensive in vitro skillset with a well-developed understanding of molecular and cellular biology immunological assays and cell transfection/ transduction and advanced cell culture techniques
Ability to design execute and troubleshoot experiments and to review analyse and interpret results
Proficiency in Python and/or R
Expertise in -omics technologies and ability to process large-scale biological datasets (e.g. single-cell/spatial transcriptomics in-house proprietary data sources such as in vitro or in vivo data)
Understanding of AI and predictive modelling tools

Desirable

Experience with genome editing technologies (CRISPR/ Cas9 base-editing transposons etc.)
Hands-on experience in T-cell functional characterization assays such as in vitro cytotoxicity proliferation cytokine measurement and multi-parameter flow cytometry
Basic experience developing cellular therapies including CAR-T/ CAR-NK TCR-T and/ or TIL therapies
Background in drug discovery and development in the pharmaceutical industry
Prior experience in UNIX-based systems and high-performance computing (e.g. SLURM) with applications to large-scale data analysis and management
Experience developing and implementing machine learning models
In vivo skillset including animal handling mouse tumour models standard routes of dosing and engraftment and tissue processing

Date Posted

04-Feb-2026

Closing Date

Required Experience:

Senior IC

Key Skills

Laboratory Experience
Mammalian Cell Culture
Biochemistry
Assays
Protein Purification
Research Experience
Next Generation Sequencing
Research & Development
cGMP
Cell Culture
Molecular Biology
Flow Cytometry

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About Company

AstraZeneca

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more

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