Research Fellow Vascular Biology, Human Genetics, and Fibromuscular Dysplasia (FMD)
Share
Job Location:
Boston, NH - USA
Monthly Salary:
Not Disclosed
Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
We are seeking a highly motivated Postdoctoral Fellow to join an international multidisciplinary research program focused on defining the human genetic molecular and cellular mechanisms underlying fibromuscular dysplasia (FMD) and related arteriopathies including spontaneous coronary artery dissection (SCAD) and cervical artery dissection (CeAD). The fellow will work within the ALIGN-FMD Network a global collaboration that integrates human genetics vascular cell biology multi-omics and in vivo modeling to advance mechanistic understanding and identify therapeutic targets for FMD.Qualifications
Key Responsibilities
- Analyze and interpret human genetic data related to FMD SCAD and CeAD including rare variant common variant and gene-burden analyses
- Integrate human genetic findings with downstream cellular and in vivo functional studies
- Design and execute experimental studies investigating vascular smooth muscle cell (VSMC) and extracellular matrix (ECM) dysfunction driven by genetically prioritized targets
- Perform and analyze in vitro and ex vivo cellular models including primary human VSMCs iPSC-derived smooth muscle cells and engineered vascular tissues
- Apply genome engineering approaches (e.g. CRISPR/Cas9-based perturbations) to model human genetic variants and regulatory mechanisms
- Contribute to murine models of arterial remodeling vascular integrity and sex-specific disease mechanisms
- Prepare manuscripts figures and presentations for peer-reviewed publication and scientific meetings
Required Skills and Experience
- PhD (or MD/PhD) in human genetics cardiovascular biology vascular biology genomics molecular biology or a related field
- Demonstrated experience in human genetics including analysis or interpretation of genome-wide association studies (GWAS) whole-exome sequencing (WES) whole-genome sequencing (WGS) or rare-variant analyses
- Strong background in cell and molecular biology ideally with experience working with vascular smooth muscle cells or related cell types
- Hands-on experience with one or more of the following:
- Genomic variant annotation and prioritization
- CRISPR/Cas9 or other genome-editing approaches
- iPSC culture and differentiation
- Murine models of cardiovascular or connective tissue disease
- Ability to work with complex datasets and translate human genetic findings into testable biological hypotheses
- Strong written and verbal communication skills with a record of or clear potential for peer-reviewed publication
- Qualified candidates please email a CV and cover letter to Dr. Mark Lindsay:
Preferred Qualifications
- Experience integrating human genetic data with functional genomics or multi-omics datasets
- Familiarity with statistical genetics bioinformatics pipelines or collaborative data analysis environments
- Experience studying extracellular matrix biology collagen remodeling or arterial biomechanics
- Interest in sex-specific genetic effects and vascular disease mechanisms
Additional Job Details (if applicable)
Physical Requirements
- Standing N/A (0%)
- Walking N/A (0%)
- Sitting N/A (0%)
- Lifting N/A (0%)
- Carrying N/A (0%)
- Pushing N/A (0%)
- Pulling N/A (0%)
- Climbing N/A (0%)
- Balancing N/A (0%)
- Stooping N/A (0%)
- Kneeling N/A (0%)
- Crouching N/A (0%)
- Crawling N/A (0%)
- Reaching N/A (0%)
- Gross Manipulation (Handling) N/A (0%)
- Fine Manipulation (Fingering) N/A (0%)
- Feeling N/A (0%)
- Foot Use N/A (0%)
- Vision - Far N/A (0%)
- Vision - Near N/A (0%)
- Talking N/A (0%)
- Hearing N/A (0%)
EEO Statement
Massachusetts General Hospital is an Equal Opportunity embracing diverse skills perspectives and ideas we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Remote Type
Work Location
Scheduled Weekly Hours
Employee Type
Work Shift
EEO Statement:
Mass General Brigham Competency Framework
At Mass General Brigham our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance make hiring decisions identify development needs mobilize employees across our system and establish a strong talent pipeline.
Key Skills
- Bioinformatics
- Genetics
- R
- Biochemistry
- Cell Biology
- Research Experience
- Statistical Software
- Cell Culture
- Molecular Biology
- Data Analysis Skills
- Flow Cytometry
- Microscopy
About Company
Patients at Mass General have access to a vast network of physicians, nearly all of whom are Harvard Medical School faculty and many of whom are leaders within their fields.
