Scientist I, Computational Chemistry
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Job Location:
Redwood City, CA - USA
Monthly Salary:
Not Disclosed
Posted on:
20 hours ago
Vacancies:
1 Vacancy
Job Summary
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionariesin a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
We are seeking a motivatedScientist I/IIto join our dynamic Computational Chemistry team. This position offers an exciting opportunity to drive drug discovery through cutting-edge computational methods working at the intersection of structural biology medicinal chemistry biology and data science to accelerate the development of transformative therapeutics for patients.
As a key contributor in our Computational Chemistry team you will:
Partner with multidisciplinary collaborative teamsin Discovery Sciences to design optimize and accelerate the discovery of novel drug candidates using structure-based computational methods.
Analyze structure-activity relationships (SAR)and make data-driven decisions by systematically following existing SAR trends to guide compound prioritization and design strategies for Ro5 and bRo5 molecules.
Partner closely with Medicinal Chemiststo prioritize compound designs both independently and collaboratively effectively communicating scientific rationale and recommendations to diverse interdisciplinary teams.
Design and implement virtual screening workflowsleveraging both structure-based and ligand-based computational methods to discover novel hit compounds and accelerate lead optimization processes.
Leverage advanced computational methodologies including physics-based methods generative models and machine learning approaches to enhance understanding of SAR and drive Ro5 and bRo5 projects with timely decision making to ensure focus and delivery of key objectives.
Provide innovative ideas and modelsto challenge and guide project roadmap while serving as lead computational chemistry representative on drug discovery pipeline projects.
Devise and execute strategiesto augment our hit finding abilities for novel protein and protein-protein targets aid in designing diverse chemical libraries.
This is a full-time on-site position based in Redwood City CA.
Required Skills Experience and Education:
Ph.D. in computational chemistry or related field.
Understanding of contemporary computational chemistry methods and their use in protein-ligand analysis and drug design such as docking virtual screening pharmacophore modeling MD simulation QM calculations etc.
Experience with computational chemistry cheminformatics data science machine learning software.
Scientific programming or scripting in Bash Python R Java C languages or similar languages.
Excellent oral and written communication skills. Experience in positively influence team decisions and effectively collaborate across multidisciplinary environments.
Driven by a desire to be innovative and creative in a high energy fast-paced environment.
Preferred Skills:
Experience with diverse Ro5 and bRo5 therapeutic modalities such as macrocycles and small molecules.
Working in HPC environments.
Strong publication history demonstrating computational chemistry expertise and innovation.
Familiarity with data visualization tools and analytics tools for effective communication of insights.
#LI-Hybrid #LI-LN1
The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role level and location. Individual base pay salary is determined by multiple factors including job-related skills experience market dynamics and relevant education or training.
Please note that base pay salary range is one part of the overall total rewards program at RevMed which includes competitive cash compensation robust equity awards strong benefits and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race color religion gender sexual orientation gender identity/expression national origin/ancestry age disability marital status medical condition and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect process and use any personal data that you provide to us in accordance with ourCCPA additional information please contact.
Required Experience:
IC
Key Skills
- Laboratory Experience
- Immunoassays
- Machine Learning
- Biochemistry
- Assays
- Research Experience
- Spectroscopy
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Data Analysis Skills
