Lead Researcher OR Associate Scientist in the Babu Group

As a part of the Center of Excellence for Data-Driven Discovery in the Department of Structural Biology at St. Jude Childrens Research Hospital the Babu Group seeks a highly driven full-time experimental Lead Researcher OR Associate Scientist with a strong background in GPCR pharmacology and signal transduction. The candidate will design and carry out high-throughput assays aimed at understanding mechanisms of G protein-coupled receptor (GPCR) signaling in human physiology and disease to develop novel therapeutic strategies.

The G Protein Coupled Receptor (GPCR) Collaborative is a recently established national collaborative between six leading GPCR biology and pharmacology experts to reveal the molecular determinants and fidelity of GPCR signaling in health and disease. The goal of the Collaborative is to gain fundamentally new insights into GPCR physiology using state-of-the-art technologies that shift focus from time-averaged ensemble investigations towards understanding the properties and functions of single molecules and assemblies in space and time. The Collaboratives Aims will be accomplished by leveraging the complementary expertise of the Collaborative members:

M. Madan Babu Member Dept. of Structural Biology St. Jude Childrens Research Hospital

Scott Blanchard Member Dept. of Structural Biology St. Jude Childrens Research Hospital

Georgios Skiniotis Member Dept. of Structural Biology St. Jude Childrens Research Hospital

Jonathan Javitch Professor of Molecular Pharmacology and Therapeutics Columbia University & NY State Psychiatric Institute

Robert Lefkowitz Chancellors Distinguished Professor of Medicine Duke University

Alice Ting Professor of Genetics Biology and Chemistry Stanford University

The ideal candidate will be an expert in GPCR pharmacology and will design and use biosensors to perform imaging high-throughput screening and functional GPCR assays in mammalian cells. This role is appropriate for a candidate holding a Masters degree and varying degrees of experience up to a recent PhD. Proven experience in GPCR pharmacology is required. Experience using optical plate readers light microscopy or flow cytometry to study GPCRs and GPCR signaling is required. This role requires an inquisitive problem-solver who thrives in a fast-paced collaborative research group with diverse expertise. The appropriate candidate is a recent PhD/MS graduate (no more than 2 y post-PhD) independently able to propose testable hypotheses based on their understanding of the GPCR literature and design and carry out experiments to test them. Please join us if you want to put your expertise in GPCR biology to work building high-throughput assay platforms to discover novel modulators of medically relevant GPCRs.

The Babu Group uses data-driven approaches to understand sequence-function relationships in intrinsically disordered proteins and structure-function relationships in medicinally important structured protein families such as GPCRs and Kinases respectively. The Lead Researcher will design and carry out experiments aimed at understanding mechanisms of G protein-coupled receptor (GPCR) signaling in human physiology and disease to develop novel therapeutic strategies. Work from our group has revealed insights into signaling mechanisms linking the ligand-binding pocket in receptors (Nature 2013 Cell 2025) to activation-dependent conformational changes (Nature 2016) the selective binding of G proteins (Nature 2017) and the allosteric activation mechanism of G proteins (Nature 2015). We have demonstrated that GPCR isoforms diversify signaling responses in different human tissues (Nature 2020) and that GPCRs are highly variable in the human population contributing to variable drug responses and posing an economic burden on healthcare systems (Cell 2018).

The Babu Group strives to build and maintain a culture of respect diversity and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.

Responsibilities and Opportunities for Skill Development

• Development of optical high-throughput assays for functional screens to dissect GPCR signaling
• Using fluorescence and FRET/BRET-based reporters of GPCR signaling and ligand binding
• Engineering mammalian cell lines
• Performing modern cellular and molecular biology workflows
• Meticulous electronic documentation of experimental observations procedures sample organization and results
• Collaborating with Structural Biologys Protein Technology Center (PTC)
• Planning and presenting research with passion and clarity
• Contribute to the development of a working hypothesis through an in-depth literature review
• Prepare high-quality manuscripts for publication in high-impact journals

St. Jude Childrens Research Hospital is consistently named as one of Fortune magazine and Best Places to Work as well as Best Workplace for Women and Best Workplace for Diversity. We are in the heart of Memphis Tennessee a vibrant and friendly city at the historic American crossroads of music trade food and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude salaries are highly competitive.

St Jude Employees receive:

• Excellent healthcare plans with zero to low health premium costs
• Onsite health clinic pharmacy and exercise facilities
• Paid parental leave and adoption assistance
• Immigration Services
• Tuition Reimbursement

Minimum Education and/or Training for either level:

• Bachelors degree in a relevant scientific area.
• A recent or anticipated PhD in GPCR biology/pharmacology/biotechnology or a Masters plus demonstrated work experience in the GPCR field is preferred.

Minimum Experience for Lead Researcher level:

• 5 years of research experience is required with a Bachelors degree.
• 3 years of research experience is required with a Masters degree.
• No additional years of research experience required with a PhD.
• Experience leading and supporting research experiments preferred.

A reasonable estimate of the current salary range is $60320 - $105040 per year for the role of Lead Researcher.

Minimum Experience for Associate Scientist level:

• 7 years of research experience is required with a Bachelors degree.
• 5 years of research experience is required with a Masters degree.
• 2 years of research experience is required with a PhD.
• Experience leading and supporting research experiments preferred.

A reasonable estimate of the current salary range is $65520 - $114400 per year for the role of Associate Scientist.

Compensation

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