Post Doctoral Fellow-MSH
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Job Location:
New York City, NY - USA
Monthly Salary:
Not Disclosed
Posted on:
10 hours ago
Vacancies:
1 Vacancy
Job Summary
Details of Research Project:
Title: Hippo pathway signaling in podocyte injury and glomerular disease
Our lab has identified Hippo pathway upstream regulator KIBRA (Kidney BRAin) protein as a novel mediator of podocyte injury via inhibition of downstream pro-survival transcriptional co-activator YAP. Our previous work has demonstrated that upregulated KIBRA podocyte expression increases susceptibility to a murine model of FSGS and also that WWC1(the gene encoding KIBRA) is a risk gene for glomerular disease progression in human podocytopathies. Preliminary data suggests that increased KIBRA/Hippo pathway activation enhances podocyte injury in a diabetic milieu. We aim to test this hypothesis and the potential therapeutic role of small molecule Hippo mediators using complementary models including immortalized podocytes hIPSC-derived podocytes and kidney organoids diabetic rodent models and banked human kidney tissue/biosamples. Other aims of this work include defining positive and negative regulators of WWC1/KIBRA expression and downstream consequences of increased Hippo pathway activity on key podocyte cytostructural elements namely the actin cytoskeleton and focal adhesion complexes.
Responsibilities
Technical Duties: (include any protocols):
- Leading laboratory projects
- Preparing figures for manuscripts and writing Results sections of manuscripts
- Training junior lab members/students
- Aseptic cell culture techniques
- Protein extraction western blotting
- RNA extraction PCR/qPCR
- Immunofluorescence/immunohistochemistry staining
- Confocal and TIRF microscopy
- Rodent animal handling urine collection and intraperitoneal/retroorbital injection
Qualifications
Educational and Other Requirements for the Position: Bachelors and Masters or Doctoral Degree
Experience Required: at least 2 years in lab environment
Goals/Outcomes of the Research Project: This work is anticipated to lead to multiple publications and to support future grant submissions in order to expand this research program
Key Skills
- Teacher Coaching
- Public Health
- Google Docs
- Classroom Experience
- Systems Engineering
- Research Experience
- Teaching
- Grant Writing
- Leadership Experience
- Mentoring
- Public Speaking
- Writing Skills
About Company
Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled ... View more
