Senior Medical Director, Rare Metabolics, US Medical Affairs

Are you ready to lead US medical strategy in rare metabolics and translate sophisticated biology into tangible impact for people living with HPP and LAL-D In this role you will set direction accelerate evidence generation and elevate scientific exchange to advance care in conditions with significant unmet need. Your leadership will shape how we engage with clinicians researchers and key institutions to improve patient journeys and outcomes.

You will guide an evolving US medical team harmonize efforts with global colleagues and ensure our scientific communications and medical education drive clarity and action. Imagine building a high-performing US Medical Affairs capability where insights from advisory boards congresses and field teams inform strategy week to weekhow will you connect those dots to sharpen our plans

Accountabilities:

• Medical Strategy Leadership: Define and deliver the US medical strategy and in-year tactical plan for rare metabolics aligning with global teams and the TA Lead to set clear priorities and field focus.

• Patient Journey and Product Strategy: Lead situational assessments of the patient journey and drive US product strategy harmonizing KOL engagement with global medical affairs across HPP and LAL-D.

• Evidence Generation: Lead and collaborate on evidence generation projects ensuring outputs inform clinical decision-making registration programs and lifecycle management.

• Scientific Communication and Education: Provide strategic guidance on scientific communications internal medical training CME and symposia medical education and medical information to ensure consistency and impact.

• KOL and Academic Partnerships: Establish strategic partnerships with KOLs and key academic institutions; work closely with field medical leadership to design and implement a targeted US KOL engagement strategy.

• Advisory Boards and Insights: Plan design and manage medical advisory boards; synthesize insights from boards field interactions and conferences into actionable updates to US medical plans.

• Registration Programs and LCM: Contribute medical acumen to registration programs with GMA and provide strategic recommendations for in-line LCM and potential pipeline assets.

• Investigator Sponsored Research: Provide medical review and ensure alignment of ISR proposals with HPP/LAL-D strategy throughout the asset lifecycle.

• Congress Representation: Represent US medical leadership at relevant US congresses elevating our scientific presence and building credibility with collaborators.

• Commercial Collaboration: Offer medical perspective to commercial strategy ensuring scientific integrity and patient-centric value in cross-functional plans.

• Budget and Resource Management: Develop implement and manage the budget plan for US rare metabolics medical initiatives optimizing resources for high-impact delivery.

• Team Support and Leadership: Provide oversight and guidance to US Medical Directors or Associate Medical Directors; support the TA Lead on team performance and delivery of medical plans.

• Medical Expertise: Serve as the medical expert and resource for the therapeutic area within the US organization enabling swift evidence-based decisions.

Essential Skills/Experience:

• Developing and implementing US strategy and plan for US MA activities for disease areas and therapeutics in rare metabolics franchise by providing medical leadership insight and strategy to the evolving US HPP/LAL-D medical team across various internal functions.

• Providing oversight and guidance to other current and/or future US Medical Directors or Associate Medical Directors in dotted line fashion

• Leading the situational assessment of the patient journey and the US product strategy development including harmonization of activities involving KOLs building from and aligned with global medical affairs HPP/LAL-D teams and personnel

• Developing in-year and future medical strategy and tactical plan for the US Medical Affairs team working closely with the TA Lead including key contributions to field focus

• Development implementation and management of budget plan for US rare metabolics Medical Team initiatives.

• Providing strategic medical recommendations for in-line life cycle management (LCM) and potential pipeline assets

• Leading and collaborating on evidence generation projects

• Contributing with scientific and medical skill to registration programs working closely with GMA

• Providing medical review and ensuring alignment with HPP/LAL-D strategy of Investigator sponsored research (ISR) proposals at proper consideration times in lifecycle

• Providing clear strategic guidance about scientific communication internal medical training external medical education (CME Symposia medical education) Medical information.

• Contributing medical perspective to commercial strategy as appropriate

• Support TA lead with teams performance in terms of goals and delivery of US medical plans

• Serving as the medical expert and resource within ALXN US in support of the therapeutic area.

• Leading content development and presentation for external medical education programs and other medical initiatives as appropriate

• Developing conducting or contributing to therapeutic training programs for Alexion personnel in conjunction with GMA training and Med Comm Leads

• Working closely with the Field team Directors in the development and execution of US KOL medical engagement strategy

Desirable Skills/Experience:

• Advanced degree (MD PhD PharmD) required

• 10 years in Medical Affairs with significant leadership experience in rare diseases metabolic disorders or related therapeutic areas

• Track record of designing and implementing US medical strategy evidence generation plans and KOL engagement at national scale

• Deep understanding of HPP and LAL-D clinical landscape diagnostic pathways and treatment paradigms

• Experience contributing to registration programs lifecycle management and ISR governance in alignment with global medical strategies

• Proven success shaping scientific communications CME and symposia content and internal medical training for field teams

• Strong cross-functional collaboration skills with commercial HEOR regulatory and compliance partners

• Demonstrated ability to manage budgets and resources while delivering high-impact medical initiatives

• Established relationships with leading academic centers and medical societies; experience representing medical leadership at major congresses

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge

perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual

flexibility.

Join us in our unique and ambitious world.

Why AstraZeneca:

Here rare disease innovation pairs the focus of a nimble biotech with the scale and resources of a global biopharma. You will work close to patients and close to your colleagues using ground breaking science and real-world evidence to bring clarity to complex conditions. We blend kindness with ambition and put unexpected teams in the same room to unleash bold thinking that turns insights into action. Your expertise will directly shape strategies that help people with devastating underserved diseases live fuller lives while you grow at pace in a collaborative learning-rich environment.

Call to Action:

Lead the US medical strategy in rare metabolics and help change the lives of people with HPP and LAL-Dstep forward and shape what comes next!

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.