Senior Scientist, Discovery- Oncology In Vivo

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

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About Oncology

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Oncology team is focused on the elimination of cancer by discovering new pathways and modalities to finding treatments and cures. We lead where medicine is going and need innovators with an unwavering commitment to results.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for a Senior Scientist Discovery-Oncology In Vivo position and is based in San Diego CA.

Role Overview
Join our Oncology In Vivo team and drive the characterization and development of small molecules biologics radioligands antibody-drug conjugates cell therapies and immune modulators for cancer treatment coordinating cross-functional teams and ensuring compliance with regulatory requirements. You will lead in vivo and ex vivo studies across multiple research programs and contribute to the advancement of innovative therapies.

Key Responsibilities

• Design execute and interpret independently in vivo pharmacology studies to validate and characterize oncology targets and therapeutic agents.
• Develop and optimize in vivo models including efficacy mechanism of action PK/PD biomarker studies and dose/schedule evaluations in diverse cancer models.
• Lead the development and adaptation of research methods from literature or internal innovation to improve existing models.
• Perform and oversee complex in vivo preclinical cancer studies ensuring scientific rigor compliance with all regulatory requirements internal quality standards and timely delivery.
• Analyze and present data using appropriate statistical methods in formats suitable for internal stakeholders and external publications.
• Collaborate across functions and contribute to projects beyond your own area acting as a scientific resource and thought leader.
• Manage multiple projects simultaneously coordinating with project leaders and external partners as needed.
• Mentor and supervise junior scientists fostering technical excellence and professional growth.
• Contribute to ex vivo analyses (flow cytometry IHC ELISA RT-PCR Luminex) and imaging studies (bioluminescent imaging for metastatic disease models) as required.
• Stay current with oncology and tumor immunology literature to integrate emerging insights into research strategies.
• Communicate clearly and professionally delivering impactful presentations and reports to internal teams and external audiences.
• Flexibility required for occasional weekend evening and holiday dosing or animal monitoring. Some onboarding training may be conducted in Spring House PA site.

Qualifications

• Bachelors degree (BS/ BA) in the life sciences (molecular/ cellular biology biochemistry pharmacology tumor immunology) with at least 10 years of relevant pharmaceutical or biotech industry/ lab/ academic experience OR a Masters degree (MS) with at least 7 years of relevant experience or PhD with 1-3 years of relevant post-graduate experience.
• Ability to cell culture of cancer and immune cells.
• Experience with oncology-relevant xenografts and syngeneic mouse models is required; primary grafts orthotopic models humanized models or genetically engineered tumor models are preferred.
• Experience with small molecules and/ or biologics is required.
• Experience with immune-modulatory agents vaccines or cell therapies such as CAR-Ts is desirable.
• Strong skills in tumor implantation techniques and dosing proper handling of therapeutics tumor measurement health monitoring and data collection and analysis are required.
• Experience with bioluminescent imaging flow cytometry IHC ELISA RT-PCR Westerns or Luminex is desirable.
• Strong organizational skills including the ability to manage several projects simultaneously; detail oriented with excellent record keeping skills are required.
• Excellent interpersonal skills with the ability to interact effectively with matrixed teams internally and externally is required.
• Excellent data management and record-keeping skills are required.
• Ability to effectively present scientific data and concepts to colleagues and teams is critical and experience presenting at external meetings is also required.
• Proven track record of adherence to animal welfare and compliance regulations is critical.
• Experience with mentoring or managing direct reports is desirable.
• Experience in writing technical drafts for patent filings IND (US-FDA) or CTA (EMA) filings is desirable.

Subject to the terms of their respective plans employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical dental vision life insurance short- and long-term disability business accident insurance and group legal insurance.

Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Companys long-term incentive program.

Subject to the terms of their respective policies and date of hire Employees are eligible for the following time off benefits:

• Vacation 120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year
• Holiday pay including Floating Holidays 13 days per calendar year
• Work Personal and Family Time - up to 40 hours per calendar year
• Parental Leave 480 hours within one year of the birth/adoption/foster care of a child
• Condolence Leave 30 days for an immediate family member: 5 days for an extended family member
• Caregiver Leave 10 days
• Volunteer Leave 4 days
• Military Spouse Time-Off 80 hours

Additional information can be found through the link below.

anticipated base pay range for this position is: $105000 - $169050

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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