Research Fellow-PC-Gastroenterology
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Job Location:
Jacksonville, FL - USA
Monthly Salary:
Not Disclosed
Posted on:
21 hours ago
Vacancies:
1 Vacancy
Job Summary
The Gubatan Lab at Mayo Clinic Florida is seeking a postdoctoral research fellow to support a basic and translational research program in inflammatory bowel disease (IBD). The lab focuses on mechanisms of IBD pathogenesis therapy resistance and host immunemicrobiome interactions using patientderived samples and established mouse models.
Research Responsibilities
The ideal candidate is a highly motivated scientist with expertise in immunology bioinformatics systems biology or related disciplines and experience in multiomics and translational research. Ongoing projects include:
Spatial transcriptomics to investigate mechanisms of therapy failure in ulcerative colitis (JAK inhibitors) and smallbowel Crohns disease (antiIL23 therapies).
Peripheral blood scRNAseq immune repertoire (TCR/BCR) sequencing and machine learning to classify IBD and predict therapeutic response.
Fibroblastimmune cell interactions in IBD.
Regulation of IgA/IgG binding to gut microbiota.
CX3CR1 regulatory B cells and hostmicrobiome interactions.
The fellow will apply singlecell and spatial transcriptomics shotgun metagenomics IgA/IgGSeq immune repertoire profiling computational methods cell culture and mouse models. Responsibilities include presenting data preparing manuscripts and supporting grant submissions. Leadership and mentoring experience is beneficial.
Technical Skills
Preferred qualifications include proficiency in:
Molecular biology (DNA/RNA isolation qPCR western blot ELISA)
Immunology techniques (flow cytometry cell isolation immunohistochemistry)
Cell culture and coculture systems
Mouse handling (genotyping injections drug administration tissue harvesting)
R and/or Python for bioinformatic analysis (transcriptomics metagenomics etc.)
Microbiology experience is a plus
Supervisory Responsibilities
Mentor laboratory technicians visiting scholars and trainees in experimental design and data analysis.
Qualifications
Ph.D. or M.D./Ph.D. in Immunology Biochemistry Molecular/Cell Biology Microbiology Bioinformatics Systems Biology or a related field.
Prior postdoctoral experience is helpful but not required. Strong background in multiomics is highly preferred.
Excellent analytical written and verbal communication skills are required.
Preferred qualifications include proficiency in:
Molecular biology (DNA/RNA isolation qPCR western blot ELISA)
Immunology techniques (flow cytometry cell isolation immunohistochemistry)
Cell culture and coculture systems
Mouse handling (genotyping injections drug administration tissue harvesting)
R and/or Python for bioinformatic analysis (transcriptomics metagenomics etc.)
Microbiology experience is a plus
Application Instructions
Interested candidates should submit a CV or NIH Biosketch and reference contact information or support letters from previous research mentors to Dr. John Gubatan at
Key Skills
- Bioinformatics
- Genetics
- R
- Biochemistry
- Cell Biology
- Research Experience
- Statistical Software
- Cell Culture
- Molecular Biology
- Data Analysis Skills
- Flow Cytometry
- Microscopy
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