UNIV Staff Scientist I Department of Neurosurgery

Job Description Summary

We are seeking a highly motivated scientist interested in brain tumor immunology a 1-year position at the Medical University of South Carolina. The scientist would be responsible in handling and processing of human brain tumor specimens including cryopreservation and tissue dissociation extraction of nucleic acids flow cytometry microscopy imaging single-cell RNA sequencing and data analysis. The scientist would also be expected to assist with animal cancer model experiments including genetic tumor models implantation of tumor cells and eventually administration of therapies. A background in molecular and cell biology immunology or neuroscience is desirable; however otherwise motivated candidates interested in brain tumor research will be considered. Interest in clinical outcomes research of brain tumors is a strong plus.

A staff scientist position at the Hollings Cancer Center (NCI-designated cancer center) of the Medical University of South Carolina is available in the newly forming Strickland Laboratory. Our primary aim is to understand the role of tumor heterogeneity and the tumor immune microenvironment as it permits immune tolerance in brain tumors. Our goal is to translate basic cancer immunology into targeted clinical immunotherapies. We are particularly interested in glioblastoma and aggressive subtypes of meningioma. We focus on the interplay of immune cell proportions and communications within the tumor immune microenvironment as it correlates with tumor progression.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type

Research Grant

Cost Center

CC000986 COM NSGY General CC

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

0.00 - 0.00 - 0.000

Scheduled Weekly Hours

40

Work Shift

Job Description

Job Duties:

30%: Assist with experimental data collections involving brain tumor human tissue processing. Collects samples (FFPE and in vivo) performs sample analyses and extracts measurement data from experiments.

30%: Assist with study design and maintenance of study organization including data entry and data storage through both document hard copies and electronically and to adapt new procedures methods or instrumentation relative to research procedures. This job duty includes organizing writing and renewing human (IRB) protocols ensuring compliance with regulations and maintaining communication with the institutional IRB.

15%: Oversee media preparation and equipment maintenance; quality control analysis reagents

10%: Supervise other personnel in the laboratory to coordinate research efforts for increased efficiency; participate in training of other lab members as needed

10%: Assist with ordering and procurement of supplies and equipment and with general maintenance of laboratory

5%: Other duties as assigned

MUSC Minimum Training and Experience:

A Ph.D. M.D. or equivalent with two years postdoctorate experience.

Additional Knowledge Skills and Abilities Preferred:

Proficiency with immunology and/or tumor genetics investigations

Familiarity with single cell RNA sequencing workflow and data processing

Familiarity with immunohistochemistry and immunofluorescence

Weekend holiday and evening work as required for experiments.

Degree of Supervision:

This position will work under direct supervision of the Strickland Brain Tumor Immunology PI which will require numerous meetings on weekly and ad hoc bases. The staff scientist will primarily work in MUSCs Hollings Cancer Center with an expectation to attend meetings and other project-related activities as necessary.

Additional Job Description

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform pinching operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 30 lbs. unassisted. (Frequent) Ability to lift objects up to 30 lbs. from floor level to height of 72 inches unassisted. (Frequent) Ability to lower objects up to 30 lbs. from height of 72 inches to floor level unassisted. (Frequent) Ability to push/pull objects up to 50 lbs. unassisted. (Infrequent) Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use initially and annually. Ability to work alone in isolated areas such as darkrooms. (Frequent)

Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes tools and equipment as required.

If you like working with energetic enthusiastic individuals you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race color religion or belief age sex national origin gender identity sexual orientation disability protected veteran status family or parental status or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications merit and business need.

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Staff IC