Senior Scientist I, CellMolecular Biology

The Toxins group within the Product Development Science & Technology (PDS&T) - Biologics organization supports manufacturing process validation regulatory submission and continuous improvement for late-stage and commercial manufacturing of biological toxin products at AbbVie. We have an exciting opportunity for a senior scientist I position based in Irvine CA. This role involves leveraging scientific and bioengineering principles to develop bioassays for analytical testing at drug substance and drug product release and stability time points. The candidate must possess in-depth knowledge and hands-on experience in a range of techniques including but not limited to molecular cloning mammalian cell culture PCR Western blot cell sorting bioassay microscopy transfection HPLC and mass spectrometry. Moreover excellent communication skills and the ability to thrive in a multi-disciplinary and cross-functional team environment are essential for success in this role.

Key responsibilities include:

• Lead scientific initiatives by generating innovative technical ideas and strategic approaches to advance research objectives and overcome experimental challenges.
• Demonstrate a strong understanding of project goals aligning research activities with broader objectives and adapting experimental plans as needed based on new data project developments or shifting priorities.
• Independently design execute and interpret complex experiments with rigorous methodology to ensure reproducibility and accurate data interpretation. Develop optimize and implement novel experimental protocols by leveraging emerging technologies to drive scientific progress and solve technical issues.
• Maintain advanced up-to-date expertise in relevant scientific and technical disciplines applying this knowledge to experimental design troubleshooting method development and integration of best practices from current literature.
• Establish and manage clear experimental timelines closely tracking progress and ensuring timely completion of project deliverables through strong organizational and time-management skills.
• Deliver high-quality scientific communication by drafting and editing SOPs technical reports publications presentations and patent applications according to industry and regulatory standards. Effectively organize analyze and present scientific ideas and experimental data to cross-functional teams and stakeholders through impactful written and oral communications.

Qualifications :

• Advanced degree in a relevant field: Ph.D. (with 6 months biopharmaceutical industry experience preferred) Masters degree (6 years industry experience) and Bachlers degree (8 years industry experience) in Cell and Molecular Biology Biochemistry Biochemical or Biomedical Engineering Biotechnology or closely related disciplines.
• Robust research background in neuroscience with direct expertise in neural cancer cell and primary cell culture 3D cell models and complex co-culture systems preferred. Demonstrated hands-on experience in developing and optimizing these models for scientific study or drug discovery applications.
• Proficient in RNA microinjection for protein expression and functional evaluations with a solid understanding of related molecular techniques. Also experienced in the generation of stable cell lines and the design and execution of novel cell-based assays.
• Highly skilled in high-resolution imaging and live-cell imaging techniques including advanced confocal microscopy fluorescence-based assays and related methodologies for monitoring cellular processes in real time.
• Extensive laboratory experience with molecular cloning mammalian cell culture PCR Western blotting cell sorting bioassays advanced microscopy transfection procedures HPLC and mass spectrometry.
• Knowledgeable in genome editing approachesincluding CRISPR/Cas9with a thorough understanding of design execution and validation of gene editing experiments.
• Previous GxP experience and attention to detail in documentation preferred.
• Demonstrated proficiency in computer skills essential for scientific research including word processing spreadsheets presentation software and advanced data analysis. Capable of analyzing interpreting and presenting complex data sets using specialized scientific software (e.g. Python R JMP). Experience with laboratory automation platforms (such as Hamilton) is highly desirable.
• Proven scientific leadership demonstrated by being the main author on published research papers and holding patents. Skilled at designing experiments solving problems creatively developing thorough experimental plans and independently troubleshooting and validating results.
• Demonstrated ability to stay current with scientific advances critically assess relevant literature and quickly integrate emerging concepts and techniques into research projects.
• Detail-oriented work style with a proven record of delivering high-quality and reproducible data within tight timelines.
• Strong interpersonal and collaborative skills enabling effective teamwork within multidisciplinary cross-functional teams. Able to communicate complex scientific information clearly through both spoken presentations and technical documentation.
• Self-motivated and adaptable with a passion for scientific discovery and a commitment to continuous learning and process improvement.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time ofthis posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic locationand we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of anybonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys soleand absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time