Postdoc in Advanced Experimental Approaches for AI-Based Protein Design DTU Bioengineering

We are seeking a highly motivated experimentalist to develop and implement innovative strategies for protein expression and screening supporting the integration of artificial intelligence in enzyme a project funded by Independent Research Fund Denmark (DFF) you will work in a team with a computationally skilled postdoc to investigate the influence of enzyme loop properties on glycoside hydrolase (GH) performance in transglycosylation.

Responsibilities and qualifications
You will work with state-of-the-art platforms including cell-free expression microbial expression high-throughput screening and state-of-the-art carbohydrate analysis to validate computational designs and generate data that advances our knowledge of enzymatic carbohydrate synthesis towards sustainable will be part of a collaborative team of PhD students and postdocs skilled in enzyme expression and characterization carbohydrate analytics computational modelling of enzymes and AI-driven enzyme design.

Your primary tasks will be to:

• Establish a high-throughput enzyme expression setup in the group supported by department-wide expertise
• Implement high-throughput screening assays to evaluate the performance of designed enzyme variants including verification of assay performance by HPLC-based analysis
• Express designed GH variants and evaluate their performance
• Supervise BSc and MSc student projects

As a formal qualification you must hold a PhD degree (or equivalent) in biotechnology biochemistry or related areas. We are looking for a candidate with the following specific and documented qualifications:

• Experience in activity assessment for carbohydrate-active enzymes preferably including assay development
• Elaborate experience in enzyme expression purification and characterization
• Experience in production of enzyme variants by site-directed mutagenesis
• Experience in HPAEC-PAD and LC-ESI-MS analysis of oligosaccharides
• Excellent communication skills in English (written and spoken).

We offer
DTU is a leading technical university globally recognized for the excellence of its research education innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 2 date is June 1^st 2026 (or according to mutual agreement). The position is a full-time position.

You can read more aboutcareer paths at DTU here.

Further information
Further information may be obtained from Associate Professor Birgitte Zeuner (bzeu@) DTU Bioengineering.

You can read more about DTU Bioengineering at

If you are applying from abroad you may find useful information on working in Denmark and at DTU atDTU Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 15 March 2026 (23:59 Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply please open the link Apply now fill out the online application form and attach all your materials in English in one PDF file. The file must include:

• Application (cover letter)
• CV
• Academic Diplomas (MSc/PhD in English)
• List of publications

Applications received after the deadline will not be considered.

All interested candidates irrespective of age gender disability race religion or ethnic background are encouraged to apply. As DTU works with research in critical technology which is subject to special rules for security and export control open-source background checks may be conducted on qualified candidates for the position.

The Department of Biotechnology and Biomedicine (DTU Bioengineering)is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in life science- and biotech industries and point towards innovation new businesses and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees of which 2/3 are scientific department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes we are helping to create a better world and to solve the global challenges formulated in the UNs 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13500 students and 6000 employees. We work in an international atmosphere and have an inclusive evolving and informal working environment. DTU has campuses in all parts of Denmark and in Greenland and we collaborate with the best universities around the world.