Postdoctoral position (ERC-funded) Cryo-ET of sperm centrosome remodeling & male infertility

Dendooven Lab — VIBVUB Center for Structural Biology (CSB) Brussels Belgium

Start date: MarchMay 2026 Duration: 4 years Funding: ERC Starting Grant

Description

We are seeking a postdoctoral fellow to join an ERC-funded project in the Dendooven Lab focused on the sperm centrosome and its role in early embryonic divisions and unexplained male-factor infertility.

Research project

While the sperm centrosome is essential for early embryonic cell divisions we still do not understand the profound centrosome reduction it undergoes during spermatogenesis and how this pathway impacts embryo development. We believe defects in this process may be key to understanding unexplained infertility.

In this project you will determine how sperm centrosomal architecture is built and remodeled in situ. You will develop and apply implement cryo-FIB lamella preparation cryo-ET and subtomogram averaging to resolve centrosomal assemblies in near-native contexts. You will also use immunohistochemistry to trace centrosome reduction in human testis tissue and develop biochemical assays to monitor centrosome reactivation after fertilization in close collaboration with a fertility clinic in Brussels. Relevant recent work includes and

Profile

You have:

• A PhD in structural biology cell biology biophysics bioengineering or a related field
• Proven ability to lead technically complex projects
• Practical experience in cryo-EM/cryo-ET and/or subtomogram averaging or outstanding computational skills applied to imaging data (Python-friendly)
• A collaborative supportive mindset and motivation for clinically relevant science

Bonus but not required

• Experience with cryo-FIB milling/lamella preparation
• Experience with subtomogram averaging workflows or tomography pipelines

What we offer

• A fully funded ERC project with a clear path toward clinical impact
• Direct access to a state-of-the-art cryo-EM facility (JEOL cryoARM300; cryo-FIB-SEM planned for 2026)
• Access to state-of-the-art computing infrastructure for image processing STA and quantitative analysis
• Competitive salary and benefits in line with VIB policies plus support for training workshops and career development

Want to apply

Send your application through the VIB job portal and include:

• Motivation letter (1page)
• Curriculum vitae
• Contact details of 2 referees

For more information you are welcome to contact Prof. Tom Dendooven ().

Deadline: 27 January 2026. We will begin reviewing applications immediately.

Diversity & inclusion

We are committed to creating and sustaining an inclusive respectful and collaborative environment where everyone can thrive. We value diversity in all its forms and welcome applications from individuals of all backgrounds and identities.