Research Associate II, Zhang Lab

The Zhang Lab at the Broad Institute of MIT and Harvard is seeking to recruit a Research Associate with expertise in proteomics and a passion for learning to join our creative diverse and dynamic research team. The Zhang lab is broadly focused on developing programmable therapeutics and working to improve human health and wellbeing. One aspect of this work is centered around analyzing the proteome peptidome metabolome and lipidome to discover new bioactive molecules as well as assess the efficacy of therapeutics we develop.

The goal of this position is to support proteomic and peptidomic projects across the lab from sample preparation to data analysis. The successful candidate will work closely with a small team of Zhang lab members to develop quantitative and qualitative proteomic and peptidomic assays including sample preparation method optimization enzymatic digestion isobaric labeling sample clean-up and data analysis pipelines. The candidate should have a strong foundation in protein biology and chemistry as well as a keen interest in protein and peptide function and interactions.

The ideal candidate will have experience in proteomics-based research or equivalent expertise in the field. Hands-on experience with mass spectrometry (LC-MS) for detailed protein characterization is essential. Prior experience in operating MS instruments is desirable. Proficiency with common proteomics data analysis software (e.g. PEAKS FragPipe DIA-NN Skyline) is highly desirable along with experience handling large datasets and performing statistical analyses of proteomics results.

The Broad Institute of MIT and Harvard provides an outstanding work environment characterized by diversity innovation and a strong commitment to worklife balance. The Zhang Lab shares this mission striving to foster a workplace culture that promotes diversity intellectual curiosity flexibility and integrity. Our lab is a fun vibrant fast-paced results-driven and collaborative environment. Broad employees receive a generous benefits packageincluding a competitive salary comprehensive health dental and vision coverage a retirement plan and additional benefitsas well as opportunities for career advancement. For more details visit: Duties and Responsibilities

• Perform proteomic and peptidomic sample preparation.
• Optimize methods for quantitative and qualitative proteomic and peptidomic assays.
• Instrument maintenance and operation.
• Process and interpret raw mass spectrometry data using specialized software (e.g. PEAKS FragPipe DIA-NN Skyline)
• Help design upstream experiments to maximize utility of mass spec data.
• Contribute to the labs research through teamwork discussion and collaboration.