Senior Research Investigator, PBPK

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Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. Read more: based pharmacokinetic (PBPK) modeling has become an important component of clinical development. PBPK models are used to characterize the drug absorption distribution metabolism and excretion (ADME) properties based on calibration to non-clinical and clinical data. This enables extrapolation and generation of hypotheses to inform clinical development. Additional applications include drug-drug interaction (DDI) risk assessment PK and dose predictions in humans and special populations prediction of target tissue concentrations and formulation optimization.

Key Responsibilities:

• Provide leadership to and collaboration with multidisciplinary project teams to develop and apply PBPK models

• Proficient in the development and application of PBPK models to address drug-discovery and development questions

• Partner with external groups to accelerate the internal PBPK efforts in key disease areas

• Provide expert support to project teams to design execute and interpret clinical pharmacology studies with supervision

• Leverage existing PBPK tools and analysis packages

• With some supervision network with stakeholders in non-clinical DMPK biotransformation and pharmaceutical development to identify and interpret experiments critical for model development and refinement

• With some supervision align PBPK model deliverables with clinical pharmacology pre-clinical and clinical development plans as appropriate

• Serve as a subject matter expert (SME) to both internal colleagues and the external scientific DMPK Translational Medicine Clinical Pharmacology community

• Stay informed with emerging literature and science in the DMPK Translational Medicine Clinical Pharmacology and PBPK fields

• Build and maintain a personal track record of publication in the area of PBPK

• Maintain an active relationship with colleagues in TMCP at the project level as well as in the advancement of Model-Informed Drug Development (MIDD)

Qualifications & Experience:

• Ph.D. in DMPK pharmaceutics clinical pharmacology engineering toxicology or a related field

• M.S. in appropriate field with significantly more experience may be considered

• 2 years of pharmaceutical industry experience in applying PBPK modeling for DDI and PK predictions

• Excellent understanding of the theory and principles in pharmacokinetics and pharmacodynamics drug disposition of small molecules and therapeutic proteins

• Understanding of the theory principles and statistical aspects of mathematical modeling and simulation

• Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop PBPK models for small molecules therapeutic proteins and new modalities.

• Ability to communicate internally and externally on topics related to translational medicine clinical pharmacology and PBPK is required

• Hands-on experience with one or more of the modeling software like Simcyp GastroPlus PKSim etc.

• Hands-on experience with general programming and data analysis tools/languages such as R Matlab Julia etc is desirable

• Desire to interact as a modeling and simulation expert with matrix project teams working closely with experts from different functional areas (pre-clinical and clinical)

• Knowledge of current practices and issues in pharmaceutical R&D in disciplines such as translational medicine and clinical pharmacology

If you come across a role that intrigues you but doesnt perfectly line up with your resume we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job such as required skills where the job is performed the employees work schedule job-related knowledge and experience. Final individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits please visit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical pharmacy dental and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account BMS Living Life Better and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan short- and long-term disability life insurance accident insurance supplemental health insurance business travel protection personal liability protection identity theft benefit legal support and survivor support.

Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited with manager approval 11 paid national holidays (not applicable to employees in Phoenix AZ Puerto Rico or Rayzebio employees)

• Phoenix AZ Puerto Rico and Rayzebio Exempt Non-Exempt Hourly Employees: 160 hours annual paid vacation for new hires with manager approval 11 national holidays and 3 optional holidays

Based on eligibility* additional time off for employees may include unlimited paid sick time up to 2 paid volunteer days per year summer hours flexibility leaves of absence for medical personal parental caregiver bereavement and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours depending on the nature of their work and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors leased workers and other service providers are not eligible to participate in the program.

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