Postdoctoral Fellow-MSH

New York City, NY - USA

Yearly Salary: $ 74692 - 80000

Posted on: 9 hours ago

Vacancies: 1 Vacancy

Job Summary

Description

Title: Postdoctoral fellow

Salary: Union-agreed

Department: Neuroscience

Physical work location: (must be proper street address): 3 E 101st St New York 10029

Name PI or Supervisor: (include phone and email): Jack Humphrey

Web link to Lab:

Web link to Department: Contact: (phone and email): Gloria Yuan

Responsibilities

Details of Research Project:

The postdoctoral fellow will lead projects funded by the BrightFocus Foundation and My Name5 Doddie to explore the role of TDP-43 in affecting gene expression and RNA splicing in the diseases Amyotrophic Lateral Sclerosis (ALS) Frontotemporal Dementia (FTD) and Alzheimers Disease (AD).

The projects will combine analysis of bulk tissue and single-cell transcriptomics with both short-read and long-read RNA-seq to identify rare cellular populations and rare mRNA isoforms in the spinal cord associated with ALS the frontal cortex in FTD and the hippocampus in AD and assess how these cells and isoforms are associated with disease pathology disease progression and genetic risk factors.

The candidate will have access to human patient tissues from the Mount Sinai Neuropathology Brain Bank the Target ALS postmortem tissue collection and the University College London Queen Square Brain Bank. The candidate will join international consortia with labs across the US and UK and attend regular monthly virtual meetings to present progress and discuss with the other groups. The candidate will attend yearly in-person meetings to present their results to a wider audience and meet in person with the other consortium members.

The candidate will join a multidisciplinary research team that includes geneticists computational biologists immunologists pathologists neuroscientists and physician-scientists at the Ronald M. Loeb Center for Alzheimers Disease within the Icahn School of Medicine at Mount Sinai. The candidate will be mentored by Dr Jack Humphrey in the Department of Neuroscience.

Qualifications

Technical Duties: (include any protocols)

Single-cell/nucleus RNA-seq analysis
Genetics of both rare and common variation
Long-read RNA-seq

Spatial Transcriptomics

Educational and other Requirements for the position: PhD in Neuroscience and/or computational biology with a focus on TDP-43 in ALS FTD or AD.

Experience Required:

Experience with single-cell datasets

Experience with genetics

Experience with RNA splicing analysis

Experience working with TDP-43 datasets
Experience re-analysing public datasets

Goals/Outcomes of the Research Project:

This work could lead to a better understanding of cellular interactions in the nervous system and how the neuronal response to specific protein pathologies shapes the course of disease. This work could lead to new biomarkers for disease progression and new therapeutic targets.

Compensation Statement

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74692.00 - $80000.00 Annually. Actual salaries depend on a variety of factors including experience education and operational need. The salary range or contractual rate listed does not include bonuses/incentive differential pay or other forms of compensation or benefits.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs) 867 - Neurosciences - ISM Icahn School of Medicine

DescriptionTitle: Postdoctoral fellowSalary: Union-agreedDepartment: NeurosciencePhysical work location: (must be proper street address): 3 E 101st St New York 10029Name PI or Supervisor: (include phone and email): Jack Humphrey Web link to Lab: Web link to Department: Contact: (phone and email): ...