Postdoctoral Fellow-MSH

New York City, NY - USA

Monthly Salary: Not Disclosed

Posted on: 12 hours ago

Vacancies: 1 Vacancy

Job Summary

Description

Title: Postdoctoral Scholar

Department: Pharmacological Sciences

Physical work location:(must be proper street address): 1425 Madison Ave New York NY 10029

Name PI or Supervisor: (include phone and email): Min Xue 212-

Web link to Lab:

Web link to Department: Contact: (phone and email): Yoori Kim 212-

Responsibilities

Details of Research Project:

The overarching goal of this project is to develop receptor-targeting cyclic peptides for drug delivery. The successful candidate will design synthesize and characterize novel peptide scaffolds engineered for improved receptor binding enhanced stability and optimized delivery properties. These peptides will be integrated into drug conjugates and delivery vehicles to improve therapeutic index tissue specificity and cellular uptake. The research spans molecule design synthesis in vitro evaluation functional screening with opportunities for collaboration across structural biology proteomics and disease-focused groups.

Technical Duties: (include any protocols)

Peptide Synthesis & Purification

Conduct solid-phase and solution-phase synthesis of cyclic and multicyclic peptides.
Optimize cyclization and bioconjugation chemistries.
Purify peptides using HPLC and other chromatographic methods.

Design & Engineering of Novel Peptide Scaffolds

Develop new backbone architectures linkers and receptor-binding motifs.
Apply structureactivity insights to improve affinity permeability and stability.
Design cell-penetrating and receptor-targeting sequences for delivery applications.

Analytical & Functional Assays

Characterize peptides using LC-MS MS/MS NMR (as applicable) and biophysical assays.
Perform biochemical cellular and reporter-based functional assays.
Conduct in vitro uptake trafficking and delivery efficiency studies.
Participate in high-throughput screening (HTS) and hit validation pipelines.

Qualifications

Educational and other Requirements for the position:
Ph.D. in Chemistry or related discipline

Experience Required:

Cyclic peptide chemistry and solid-phase peptide synthesis.
Cell-penetrating peptide (CPP) design and biochemistry.
Chemical biology techniques relevant to peptide modification and conjugation.
High-throughput screening (HTS) and data-driven hit validation.
Analytical characterization (LC-MS HPLC mass spectrometry).
Functional biochemical or cell-based assays.
Strong organizational documentation and communication skills.
Ability to work both independently and collaboratively in a fast-paced research environment.

Goals/Outcomes of the Research Project:

The postdoctoral researcher will drive a program aimed at:

Identifying novel cyclic peptide ligandsfor specific cell-surface receptors.
Developing delivery-competent peptide scaffoldswithoptimized receptor binding and cell penetration.
Generating and characterizing drugpeptide conjugatesfor targeted delivery.
Producing mechanistic insights that support preclinical development.
Delivering high-impact publications technology disclosures and potential translational opportunities.

Successful completion of this project is expected to yield receptor-targeting cyclic peptidesthat advance drug delivery for oncology immunology and molecular imaging applications.

DescriptionTitle: Postdoctoral ScholarDepartment: Pharmacological SciencesPhysical work location:(must be proper street address): 1425 Madison Ave New York NY 10029Name PI or Supervisor: (include phone and email): Min Xue 212-Web link to Lab: Web link to Department: Contact: (phone and email): Yoor...