Biomarker Scientist

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets led by VYVGART our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG and with the potential to treat patients across dozens of severe autoimmune diseases.

We are building a new kind of biotech company one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company our partnerships our science and our people because when we do we deliver more for patients.

argenx is a fast-growing clinical-stage biopharmaceutical company focused on developing innovative antibody-based therapies to improve the lives of people with severe autoimmune diseases. Leveraging our unique antibody engineering technologies and the complementary expertise of our global team we have built a differentiated pipeline of novel product candidates tailored from discovery through development to meet specific patient needs. As we expand our therapeutic franchises across neuromuscular neurology rheumatology and nephrology indications we remain deeply committed to our core values of collaboration empowerment humility innovation and excellencealways staying science-based data-driven and patient-focused.

For the expansion of the Translational Science team argenx is actively looking for a highly motivated Biomarker Scientist with expertise in immunology research. As a Biomarker Scientist you take on a key role in supporting biomarker strategies to enable stratified medicine/diagnostic approaches (where appropriate) and overall to enhance the probability of successful drug development and approval. You will support the discovery and implementation of disease-specific biomarkers and biomarkers for patient selection. You will work in close collaboration with internal and external project teams. We are specifically looking for a polyvalent scientist keen to work on different projects with knowledge on the selection development analytical validation and outsourcing of clinically applicable biomarker assays.

This position is based at our facility in Zwijnaarde Belgium and requires regular on-site presence with flexible remote working possibilities.
We look forward to receiving your CV and cover letter when applying. A cover letter is mandatory for your application to be considered.

Main roles & responsibilities

• Participate in the selection of biomarkers to measure predictive pharmacodynamic and safety biomarkers including biomarkers supporting treatment response disease understanding and Mode-of Action
• Translate the biomarker context of use (COU) into analytical requirements and ensure fit-for-purpose assay and vendor selection
• Drive the implementation of biomarker assays including assay development and validation as well as biomarker sample analysis both internally and/or in collaboration with external vendors or academic collaborators
• Act as a subject matter expert in ligand binding assay biomarker technologies ) and their development and implementation in clinical programs
• Support data analysis in line with COU and clinical development strategy
• Work across projects to assure harmonization of biomarker assay implementation and data interpretation
• Review and provide input in clinical trial documents (protocols reports DTAs lab manuals ICFs) and contribute in interactions with regulatory agencies
• Contribute to the growth and further development of the Translational Science team

Professional experience / expertise

• PhD in Immunology or Molecular Biology with at least 3 years of relevant research / industry experience or Masters degree with extensive industry experience in analyzing human samples and/or monitoring analysis of biomarkers during clinical trials

• Pharma / Biotech experience in the development & implementation of biomarker strategies and methods to support drug development
• Proven track record / publications in innovative science / pathobiology
• Experience of disease areas / conditions aligned to argenxs core immunology-focused ambitions
• Direct experience with the characterization of biomarkers using ligand binding assays; experience with other analytical platforms such as flow cytometry proteomics molecular biology and/or immunohistochemistry is considered a plus
• Understanding of concepts such as COU and and fit-for-purpose biomarker assay validation and how to apply these
• Experience in implementing biomarker assays (development and validation) in clinical studies and analysing corresponding data
• Experience in managing outsourced activities at external vendors
• Understanding of GCP/GCLP guidelines and current global regulations

Profile:

• Profound medical / scientific knowledge especially in the fields of immunology
• Resilience with the ability to adapt to changes in priorities and to work effectively on multiple programs in a fast-paced environment
• Motivated enthusiastic accurate in execution and reporting
• Strong project organization and interpersonal skills
• Good communication skills and good written and oral English language skills
• Team-player capable to collaborate effectively with internal and external stakeholders

Offer:

• Full time position within a dynamic fast-growing and human-sized biotech company driven by science creativity and innovation
• Work in a cross-functional team with access a broad array of technologies
• Opportunity to contribute to the continued build out of the Translational Science team
• A competitive salary package with extensive benefits
• Possibility to balance onsite presence and remote work with limited travel required Relocation to Belgium will be preferred

At argenx all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race color religion sex sexual orientation gender identity national origin protected veteran status disability or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer.

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