PhD Student (w/m/d)

Institute of Anatomy

Your tasks

• Execution of a research project dealing with the
  biology of stem cells in the larval Drosophila gut
• Bioinformatic analysis of various high-throughput
  sequencing datasets (single nucleus RNAseq
  DamID) genetic cell biological and imaging
  experiments in the model organism Drosophila
• Teaching of undergraduate medical students in
  histology

Your profile

• Applicants holding a Master degree in biology or a related subjectwith a profound interest in cell biology developmental biologybioinformatic analysis of single cell RNAseq data imaging andgenetics are encouraged to apply. Laboratory experience in cellbiology molecular biology and biochemistry is desirable.
• Motivation to work in an international research team and goodcommand of the English language is mandatory.

Our offer

• Everything but ordinary: You can expect a secure job in a challenging innovative environment including company pension schemes and regular working hours without business trips.
• Work-life balance: Whether full-time or part-time with or without children with numerous support options we will find the right path together.
• Team spirit in R(h)ine culture: You will be warmly welcomed by an interdisciplinary team that values mutual respect and helpfulness.
• Strong perspectives: We offer extensive training opportunities so you can continuously grow and set new goals.

Your future with us

We are one of the leading university hospitals in Germany and network research teaching and health care at the highest level. Thats why many things are a lot bigger for us: the spectrum of exciting development opportunities. The limitless openness with which specialists from all over the world work together here. Or our commitment as an employer to support all employees as best we can in reconciling their job with their goals and life situations.

This is the University Hospital of Cologne: Everything but ordinary.

Your future in detail

We are searching for a highly motivated candidate who is interested instudying the molecular mechanisms controlling stem cell maintenanceand cell fate determination in the model organism Drosophila. The projectdeals with the functional analysis of target genes regulated by the Tip60chromatin remodeling complex of the fruit fly Drosophila. We found that theATPase Domino the histone acetyl transferase Tip60 and several othermembers of this protein complex including the transcription factor Myc arerequired for maintenance of neural stem cells in the larval fly brain (Rust etal. 2018). More recent data show that the Tip60 complex is also requiredfor stem cell maintenance in the larval gut of the fly. By using the DamIDmethod we have identified target genes of the Tip60 complex in the gut andaim to functionally analyze their contribution to tissue homeostasis. Wehave also pursued single nucleus RNA sequencing of the wild type anddomino knockdown larval gut and are in the process of assembling a cellatlas of the larval gut based on these data and on electron microscopic
imaging. Further information on the research activities of our group can befound on our homepage: Applications from female candidates are expressly welcome and will be given priority in the event of equal suitability competence and professional performance. People with disabilities are welcome to apply and will be treated preferentially in the event of equal suitability and qualification.

Contact

Univ.-Prof. Dr. A. Wodarz
Tel: 49 0

Application deadline: 28.12.2025

Job-ID: 8a3y3zih