Special Project Associate II-Neuroscience-Translational Neuroproteomics Laboratory (Rossoll Lab)

The Translational Neuroproteomics Laboratory directed by Dr. Wilfried Rossoll is seeking a highly motivated and detail-oriented project associate to join our team in the Department of Neuroscience. Our group investigates how abnormal protein aggregation drives neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) frontotemporal dementia (FTD) Alzheimers disease (AD) and related proteinopathies.

Our research combines state-of-the-art mass spectrometrybased proteomics advanced fluorescence microscopy and a range of molecular and cellular approaches to define the molecular composition of disease-associated protein aggregates. We focus primarily on TDP-43 and tau key pathological proteins in ALS FTD and AD while also studying related aggregates such as α-synuclein in Parkinsons disease and Lewy body dementia. By identifying molecular drivers and modifiers of aggregation our goal is to uncover new therapeutic targets and develop strategies to slow or prevent disease progression.
Using insights gained from proteomic and mechanistic studies our team conducts experiments in cellular and animal models to determine how aggregates form spread and cause toxicity. These studies directly support our broader mission of developing and validating therapeutic approaches for neurodegenerative proteinopathies.

For more information about our research program please visit:
are looking for an enthusiastic individual with a strong interest in neuroscience and a desire to learn new techniques. The ideal candidate will bring curiosity attention to detail and basic laboratory and computer skills. Experience with molecular biology cell biology or biochemical methods is advantageous. We offer a supportive collaborative environment with individualized training mentorship and opportunities for career development.

The successful candidate will perform diverse laboratory tasks including:
Immunohistochemistry on cultured cells and tissue sections
Mammalian cell culture
Fluorescence microscopy
Protein affinity purification and biochemical assays
Sample preparation for mass spectrometry
General laboratory support record-keeping and data organization

The position is considered non-exempt (hourly) and therefore all hours worked must be recorded. A Special Project Associate at Mayo Clinic is a temporary position intended to execute experimental studies in support of lab goals and grant commitments as designated by the Principal Investigator. Performs basic statistical data analysis; prepares tables charts/graphs and assists in organizing data; completes assorted laboratory procedures and assays. Proof of English proficiency is required for J-1 Short-Term Scholars Research Scholars Professors Specialists and Student Interns sponsored by Mayo Clinic.

The following is required for completeness of application: Current curriculum vitae with bibliography Proof of highest degree received (if awarded a Bachelors or Masters degree). Please also be prepared that you may be asked to provide two letters of recommendation to the hiring PI prior to an interview.

• B.S. in Biology Neuroscience Biochemistry or a related field
• For J-1 visa sponsorship a Masters degree is required
• Prior experience in molecular biology cell biology or biochemistry is an advantage
• Must have a solid understanding of lab techniques equipment and safety.