Scientist III (Oligonucleotides Pharma)
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Job Location:
Monthly Salary:
Posted on:
14 hours ago
Vacancies:
1 Vacancy
Job Summary
Work Schedule
Standard (Mon-Fri)Environmental Conditions
Adherence to all Good Manufacturing Practices (GMP) Safety StandardsJob Description
Scientist III - Pharma/Oligonucleotides
At Thermo Fisher Scientific youll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research development and delivery of life-changing therapies. With clinical trials conducted in 100 countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio our work spans laboratory digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on now and in the future.
Location/Division Specific Information
Our PPD Laboratory Services team has a direct impact on improving patient health through the expertise of scientists industry thought-leaders and therapeutic guides. As the world leader in serving science our laboratory professionals bring their commitment to accuracy and quality to deliver groundbreaking innovations. This role will be based at our GMP Laboratories in Athlone Ireland and will work within a team specifically working with Oligonucleotides.
Discover Impactful Work:
The role of Scientist III is to perform a variety of complex sample preparation and analysis procedures to quantitatively measure small molecules using a wide range of analytical instrumentation. Working mainly independently Scientists will interpret analytical data in regard to acceptability and consistency and set up and maintain analytical instrumentation.
A day in the Life
Perform a variety of complex sample preparations
Analysis procedures to quantitatively measure pharmaceutical compounds in a variety of formations for stability testing and other studies for analytical testing support
Review and compilation of results
Performing work assignments accurately timely and in a safe manner
Training on routine operation maintenance and theory of analytical instrumentation SOPs and regulatory procedures and guidelines.
Works with multiple functional groups to meet business needs.
Sets up and maintains analytical instrumentation.
Trains on routine operation maintenance and theory of analytical instrumentation SOPs and regulatory procedures and guidelines.
Ensures QA findings are addressed appropriately.
Communicates project status to project leader.
Performs work assignments accurately and in a timely and safe manner.
Reviews interprets and analyses data for technical quality and compliance to protocols methods SOPs client criteria and Good Manufacturing Practices (GMP) or Good Laboratory Practices (GLP).
Education and Experience
Educated to a bachelors degree level in a relevant area ie chemistry biochemistry
5 years relevant industry experience within a GMP laboratory
The applicant should have a 5 years analytical experience with oligonucleotide molecules (ASO and siRNA) for both Drug Product and Drug Substance
Proficient in Waters and AgilentHPLC and UPLC models and various detectors (UV DAD/PDA ELSD).
In some cases an equivalency consisting of a combination of appropriate education training and/or directly related experience will be considered sufficient for an individual to meet the requirements of the role.
Knowledge Skills Abilities
HPLC:
Purity and impurity analysis of Denaturing and Non-denaturing HPLC Ion chromatography methods.
- Experience with Agilent and Waters HPLC and UPLC models.
- Experience with various detectors (UV DAD/PDA ELSD).
- Integration of oligonucleotide chromatographic profiles.
- Empower apex tack and traditional integration algorithm experience.
Mass Spec
Identification Purity and Impurity analysis using Mass Spectrometry
Extraction of oligonucleotide Mass spec data.
- Experience with single Quadrupole Mass Spectrometer with Electrospray ionisation
- Experience with Agilent OpenLab Chemstation
T-melt analysis
UV spectrometry pH Dissolution Osmolality Karl Fisher
Proven ability to interpret data by performing trend analysis
Proven technical writing skills
Proven problem solving skills
Detailed knowledge of method validation; method development would be an advantage.
The ability to plan schedule and carry out work for successful project completion
A positive attitude and ability to work well with others
The ability to write protocols and reports with minimum supervision
Excellent attention to detail
Be able to communicate effectively and follow detailed written and verbal instruction
Our Mission is to enable our customers to make the world healthier cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100000 colleagues we share a common set of values - Integrity Intensity Innovation and Involvement - working together to accelerate research solve complex scientific challenges drive technological innovation and support patients in need.
#StartYourStory with PPD part of Thermo Fisher Scientific where diverse experiences backgrounds and perspectives are valued.
Apply today! http://j
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race color religion sex sexual orientation gender identity national origin protected veteran status disability or any other legally protected status.
We welcome and encourage applicants from outside of Ireland. We can provide support with immigration and visa needs for successful applicants and dependents tax consultations and other basic destination services. All other relocation costs are at the expense of the applicant.
Key Skills
- Laboratory Experience
- Immunoassays
- Machine Learning
- Biochemistry
- Assays
- Research Experience
- Spectroscopy
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Data Analysis Skills
About Company
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