Associate Scientist, Post Doctoral Fellow, Neuroimmunology

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers designed to provide you with an academic focus in a commercial environment. With the resources reach and expertise of a large pharmaceutical company postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Our organizations Discovery Neuroimmunology team is seeking a highly motivated intellectually curious postdoctoral fellow to drive innovative research aimed at defining mechanisms of neuroinflammation and microglial biology in neurodegenerative diseases. A successful candidate will independently conduct experiments to validate in vitro and in vivo models evaluate mechanistic hypotheses and identify candidate translational biomarkers. They will also collaborate with a multidisciplinary team of scientists working to advance novel immune-based therapies for CNS diseases. The ideal candidate will have a background in neuroscience molecular cell biology and / or immunology the ability to flex between in vitro and in vivo model systems and have a strong interest in drug discovery.

KEY RESPONSIBILITIES

• Proactively conduct experiments to advance research objectives and collaborate across discovery teams (medicinal chemistry pharmacology data science) and with external academic or industry partners.

• Develop and characterize in vivo murine models of neuroinflammation and neurodegenerative pathologies such as those in Alzheimers and Parkinsons disease.

• Design and execute mechanistic in vivo in vitro or ex vivo studies.

• Integrate and interpret data generated from transcriptomic and proteomic studies to inform translational biomarkers.

• Monitor scientific literature and incorporate new findings into project strategies.

• Communicate results clearly through internal and external presentations and scientific publications

EDUCATION

• A PhD within 6 months of hire in neuroscience immunology molecular cell biology or related discipline is required.

• Research experience in neurodegeneration or microglial biology is strongly preferred.

REQUIRED

• Extensive hands-on experience in developing and characterizing murine models to assess CNS biology or therapeutic intervention.

• Proficiency with murine handling oral and injection-based dosing blood collection and performing necropsy procedures including cardiac perfusion and brain and/or spinal cord extraction.

• Experience processing and profiling tissues using a broad range of techniques including single and/or multi-plexed immunoassays RNA/protein analysis and immunohistochemistry.

• Proficiency in data science skills to perform processing and interpreting transcriptomic/proteomic datasets using bioinformatic tools and statistical methods.

• Creative and inquisitive mindset eager to showcase independent research leadership and apply to CNS drug discovery.

• Excellent communication skills with the ability to effectively collaborate with cross-functional teams and present research findings both internally and externally.

• Strong publication record demonstrating research excellence in experimental design execution data analysis and manuscript preparation.

PREFERRED

• Experience with stereotactic intracerebral / intracerebroventricular injections or cannula implantation sub-dissecting brain regions and / or collecting cerebrospinal fluid from mice or rats.

• Experience with CNS cell isolation sorting and flow cytometry for transcriptomics analysis

• Experience culturing immune cell lines primary murine microglia and iPSC-derived cells.

• Experience managing and coordinating use of transgenic mouse lines.

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