Research Scientist (Kelada Lab)
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Job Location:
Chapel Hill, NC - USA
Monthly Salary:
$ 80000 - 85000
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Position Summary
Dr. Samir Keladas Laboratory in the Department of Genetics in the UNC School of Medicine is seeking a Research Scientist Kelada Labs research is aimed at identifying gene-environment interactions with air pollution exposure that affect the development and progression of respiratory diseases. The primary purpose of this new position is to design execute and analyze experiments using mouse models of air pollution-induced respiratory disease with a focus on identifying genetic and genomic predictors of adverse responses. Working with the Supervisor and other the lab members the research scientist will oversee large-scale projects that involve measuring pulmonary and immune responses to air pollution across inbred strains of mice using a variety of measurement approaches including flow cytometry and isolating specific cell types of interest by flow sorting for subsequent analysis of gene expression and potentially epigenomic endpoints (e.g. chromatin accessibility). Thereafter the research scientist will carry out both basic and complex statistical analyses of the data including characterizing the effect of air pollution exposure on pulmonary and immune responses analysis of differential gene expression in specific cell types and in some cases carry out spatial transcriptomic analyses of specific lung regions. Finally the research scientist will conduct quantitative genetic analysis (i.e. QTL mapping) of specific endpoints measured in mouse experimental addition to carrying out these research projects the research scientist will also be expected to lead efforts to present the results of these projects in lab meetings and conferences. Thus strong scientific communication skills are fundamental for this position.
Required Qualifications Competencies And Experience
Post-doctoral fellowship in a related field and/or experience in other industry or government setting.
Preferred Qualifications Competencies And Experience
PhD in genetics/molecular biology or toxicology/environmental health. Experience with mouse models of environmentally-induced pulmonary disease including phenotyping using bronchoalveolar lavage and tissue collection Flow cytometry and FACS sorting of cellular populations isolated from the murine lung and other organs. Demonstrated proficiency with standard statistical approaches for biomedical data using R software Demonstrated proficiency in analysis of bulk RNA -seq data using R software including visualization approaches Proficiency with design spatial transcriptomics experiments and resulting data analysis Experience with quantitative trait locus mapping methods in experimental crosses Experience in giving scientific presentations
Dr. Samir Keladas Laboratory in the Department of Genetics in the UNC School of Medicine is seeking a Research Scientist Kelada Labs research is aimed at identifying gene-environment interactions with air pollution exposure that affect the development and progression of respiratory diseases. The primary purpose of this new position is to design execute and analyze experiments using mouse models of air pollution-induced respiratory disease with a focus on identifying genetic and genomic predictors of adverse responses. Working with the Supervisor and other the lab members the research scientist will oversee large-scale projects that involve measuring pulmonary and immune responses to air pollution across inbred strains of mice using a variety of measurement approaches including flow cytometry and isolating specific cell types of interest by flow sorting for subsequent analysis of gene expression and potentially epigenomic endpoints (e.g. chromatin accessibility). Thereafter the research scientist will carry out both basic and complex statistical analyses of the data including characterizing the effect of air pollution exposure on pulmonary and immune responses analysis of differential gene expression in specific cell types and in some cases carry out spatial transcriptomic analyses of specific lung regions. Finally the research scientist will conduct quantitative genetic analysis (i.e. QTL mapping) of specific endpoints measured in mouse experimental addition to carrying out these research projects the research scientist will also be expected to lead efforts to present the results of these projects in lab meetings and conferences. Thus strong scientific communication skills are fundamental for this position.
Required Qualifications Competencies And Experience
Post-doctoral fellowship in a related field and/or experience in other industry or government setting.
Preferred Qualifications Competencies And Experience
PhD in genetics/molecular biology or toxicology/environmental health. Experience with mouse models of environmentally-induced pulmonary disease including phenotyping using bronchoalveolar lavage and tissue collection Flow cytometry and FACS sorting of cellular populations isolated from the murine lung and other organs. Demonstrated proficiency with standard statistical approaches for biomedical data using R software Demonstrated proficiency in analysis of bulk RNA -seq data using R software including visualization approaches Proficiency with design spatial transcriptomics experiments and resulting data analysis Experience with quantitative trait locus mapping methods in experimental crosses Experience in giving scientific presentations
Required Experience:
Staff IC
Key Skills
- Laboratory Experience
- Machine Learning
- Python
- AI
- Bioinformatics
- C/C++
- R
- Biochemistry
- Research Experience
- Natural Language Processing
- Deep Learning
- Molecular Biology
About Company
The University of North Carolina at Chapel Hill, the nation’s first public university, is a global higher education leader known for innovative teaching, research and public service. A member of the prestigious Association of American Universities, Carolina regularly ranks as the best ... View more
