Master Thesis Interference of Therapeutic Antibodies in Olink Biomarker Assays
Share
Job Location:
Monthly Salary:
Posted on:
06-11-2025
Vacancies:
1 Vacancy
Job Summary
Work Schedule
Standard (Mon-Fri)Environmental Conditions
Some degree of PPE (Personal Protective Equipment) required (safety glasses gowning gloves lab coat ear plugs etc.)Job Description
Location: Olink part of Thermo Fisher Scientific Uppsala Sweden (On site).
Duration: JanJune 2026
Supervisor: Emmy Rannikko
Project Overview
Are you interested in working at the intersection of bioanalysis and drug development This thesis project addresses a highly relevant challenge: how therapeutic antibodies may interfere with biomarker measurements in plasma using Olink assays. You will have the opportunity to combine work with Olinks Proximity Extension Assay (PEA) technology and advanced biophysical methods to explore mechanisms in a real research setting.
Objectives
Screening: Test a selection of known therapeutic antibodies in plasma (spike-in) and analyze interference using mid-plex PEA readouts.
Deep Dive: Perform titrations for selected antibodies and investigate detailed effects.
Mechanistic Studies: For selected cases verify interactions using SPR (Surface Plasmon Resonance) technology.
Optional (time permitting): Explore and compare with plasma samples endogenously treated with therapeutic antibodies based on assay signatures.
Why Its Exciting
The results will provide insights into how therapeutic antibodies affect biomarker measurementscritical for both clinical studies and diagnostics. You will gain hands-on experience with modern proteomics platforms and biophysical interaction analysis.
About You
Interested in bioanalysis proteomics and pharmaceutical research.
Enjoy combining experimental work with data analysis and problem-solving.
Currently pursuing a masters degree in biotechnology biomedicine molecular biology or a related field.
About Thermofisher:
ThermoFisher Scientific is a world leader in serving science with a mission to enable our customers to make the world healthier cleaner and safer. Our extensive portfolio includes innovative technologies cutting-edge research and comprehensive laboratory services that support a wide range of industries including pharmaceuticals biotechnology healthcare environmental and industrial applications.
At ThermoFisher Scientific we are committed to providing exceptional solutions that drive scientific discovery and improve patient outcomes. Our global team of over 130000 employees works collaboratively to deliver high-quality products and services ensuring that our customers can achieve their scientific goals with confidence and precision.
Apply now!
By joining ThermoFisher Scientific you will be part of a dynamic and inclusive workplace where your contributions can make a significant impact on advancing science and technology for the betterment of society.
Key Skills
- Dermatology
- Communication
- Excel
- Furniture
- Airlines
- Jboss
About Company
Electron microscopes reveal hidden wonders that are smaller than the human eye can see. They fire electrons and create images, magnifying micrometer and nanometer structures by up to ten million times, providing a spectacular level of detail, even allowing researchers to view single a ... View more
