Senior Director, Clinical Practice Liaisons

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) a liver disease with high unmet medical need. Madrigals medication Rezdiffra (resmetirom) is a once-daily oral liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

The Sr. Director Clinical Practice Liaison (CPL) is a key field-based leadership position responsible for the strategic and tactical oversight of the CPL team within a defined U.S. region. This individual will play a critical role in managing and developing CPLs ensuring the team executes against the companys medical strategy complies with regulatory and internal policies and delivers scientific value to both internal and external stakeholders.

This position will interface regularly and compliantly with cross-functional colleagues (e.g. Marketing Sales Market Access Clinical Operations HQ Medical Affairs) and external partners including Thought Leaders (TL) healthcare decision-makers and other relevant stakeholders.

Key Responsibilities

• Team Leadership & Development

• Recruit coach and manage performance of regional CPLs

• Foster continuous development through mentoring and training

• Align CPL activities with strategic objectives and tactical plans

• Medical Strategy Execution

• Drive implementation of regional field medical strategies

• Translate national objectives into actionable regionally tailored activities

• Partner with cross-functional teams to integrate field insights into medical planning

• Cross-functional Collaboration

• Collaborate closely with Sales Marketing Market Access and Clinical Operations

• Serve as a field-based liaison for HQ Medical Affairs initiatives

• Contribute to launch readiness and lifecycle management strategies

• Clinical Trial Support

• Collaborate with Clinical Operations to ensure successful study execution based upon recognized needs

• Congress & External Engagement

• Represent Medical Affairs at U.S. medical congresses in a compliant manner

• Coordinate booth planning scientific exchange competitive intelligence and post-conference debriefs

• Strategic Team Building

• Contribute to the design and structure of the U.S. Field Medical team

• Identify evolving business needs and adjust regional capabilities accordingly

• Compliance & Quality

• Ensure all CPL activities comply with company SOPs industry standards and applicable regulations

• Uphold the highest ethical standards in all external engagements

• Travel Requirement

• Willingness to travel 2575% for congresses site visits and stakeholder engagement

Qualifications & Experience

• Advanced degree in a scientific or healthcare discipline (MD PharmD PhD DNP etc.)

• Minimum 5 years of Medical Affairs experience including at least 3 years as an MSL or equivalent (translatable clinical practice experience will be considered)

• Minimum 3 years of people management experience or formal leadership development participation

• In-depth knowledge of clinical medicine and medical research; experience in cardiometabolic health or MASH/NASH preferred

• Proven ability to understand communicate and translate complex scientific information

• Strong knowledge of U.S. healthcare system FDA regulations and medical affairs compliance standards

• Demonstrated cross-functional collaboration project execution and strategic planning skills

• Proficiency in Microsoft Office Suite virtual communication platforms (e.g. Zoom) and CRM systems (e.g. Veeva)

Preferred Attributes

• Strong interpersonal presentation and relationship-building skills

• Adaptable and proactive in a fast-paced evolving environment

• Passion for mentoring team building and field-based medical innovation

#LIRemote

Madrigals Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

All employees receive equity which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidates qualifications skills education experience business needs and market demands. The base salary range for this position is $262000 - $320000 per year.

All full-time employees receive equity which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance we empower employees to think like owners giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits including flexible paid time off medical dental vision and life/disability insurance and 401(k) offerings (i.e. traditional Roth and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance legal services and other addition we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal state and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance please contact

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications merit and business need. Applicants will receive consideration for employment without regard to race ethnicity color religion sex gender identity sexual orientation national origin age disability protected veteran or disabled status or other characteristic protected by applicable federal state or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

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