Postdoc Research Fellow NEUROLOGY
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Job Location:
Boston, NH - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
A postdoc position is open in the laboratory of Silke Nuber in the Ann Romney Center for Neurologic Diseases in the Department of Neurology Brigham and Womens Hospital and Harvard Medical School to study alpha-synuclein biology in mice and cell culture models of Parkinsons disease (PD). The research focuses on determining whether gender or lipid-dependent changes that affect the alpha-synuclein tetramer:monomer ratio early in Parkinsons pathology confer neuroprotection to specific neurons and brain regions.The PIs previous work demonstrated that upstream abrogation of normal -synuclein tetramers the key protein in Lewy body pathology induces a progressive L-DOPA-responsive motor syndrome and cortical and dopaminergic fiber loss in familial PD E46K (1K) and 3K mutant mice. The new project uses these unique mouse models to study early-onset addition new models will be generated to analyze tetramer abrogation by other familial PD -synuclein mutations. Effects include behavioral testing as well as molecular biochemical and neuropathological analyses.
Candidates must have extensive experience working with mice including neonatal injections. Prior work with primary neurons and/or induced human neurons required. Only candidates with demonstrated expertise and publications in molecular biology biochemistry cell biology and animal husbandry should apply.
Qualifications
Requirements
A Ph.D. in neuroscience biochemistry or a related biological field.
Excellent track record of publications including in neurodegenerative disease.
Extensive experience with mouse studies including behavior listed in detail in the CV.
Experience in molecular biology pathology and biochemistry listed in detail in the CV.
Cell culture (primary neurons and/or induced human neurons) experience preferred listed in detail in the CV.
Self-motivated and driven individual able to work both independently and in a team environment.
Excellent oral and written communication skills in English.
Minimum three-year commitment.
Compensation will follow NIH postdoctoral stipend levels. Applicants should submit a cover letter detailing their research experience a CV a potential start date and full contact information for three reference to;
Additional Job Details (if applicable)
Remote Type
Work Location
EEO Statement:
Mass General Brigham Competency Framework
At Mass General Brigham our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance make hiring decisions identify development needs mobilize employees across our system and establish a strong talent pipeline.
Key Skills
- Bioinformatics
- Genetics
- R
- Biochemistry
- Cell Biology
- Research Experience
- Statistical Software
- Cell Culture
- Molecular Biology
- Data Analysis Skills
- Flow Cytometry
- Microscopy
About Company
Patients at Mass General have access to a vast network of physicians, nearly all of whom are Harvard Medical School faculty and many of whom are leaders within their fields.
