SeniorPrincipal Research Associate, Biochemistry and Cellular Neurodegeneration (dfm)
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Job Location:
Basel - Switzerland
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
At Roche we believe it is urgent to deliver medical solutions right now and we are passionate about transforming patients lives. We are looking for a highly motivated research associate to join our team in Pharma Research and Early Development (pRED).
The Opportunity
As a Senior/Principal Research Associate you will be an integral member of our Protein Interactions lab within the Neural Signalling Section a dynamic research unit at the heart of the Neuroscience and Rare Disease (NRD) therapeutic area. The overarching goal of the Neural Signalling Section is to move forward drug discovery projects from target assessment to early clinical phase in the therapeutic area of neurodegenerative diseases such as Alzheimers disease and Parkinsons disease. You will collaborate closely with experts across various laboratories within NRD as well as with teams from other departments in the collaborative drug discovery matrix of pRED to translate research hypotheses into innovative therapeutics that address brain disorders:
Biochemistry of Protein Aggregation: Generate and characterize different aggregation states of proteins from recombinant proteins and human brain tissue homogenates using biochemical methods.
Cell Culture: Support the team with developing and characterizing Tau mutant cell lines iPSC neurons and brain organoids. You will also establish and validate various protein complementation functional and seeding assays in cell culture.
Scientific Communication: Present your findings at internal project team and department meetings.
Collaboration & Leadership: Work closely with all group members share lab organizational duties and actively contribute to a positive and collaborative work atmosphere. You will also provide guidance and knowledge sharing to fellow research associates scientists and students.
Who You Are
We are looking for someone with a deep scientific curiosity and a drive for innovation. You work independently but also excel in a collaborative and inclusive team environment:
Required Qualifications: You have a bachelors or masters degree in neuroscience biology biochemistry life sciences biomedicine or a related field with at least 5 years of laboratory experience or are holding a Biology Research Associate apprenticeship certificate or similar vocational training with several years of industry lab experience. Strong laboratory expertise in Tau biology or other intrinsically disordered proteins is required.
Preferred Experience: You bring extensive hands-on lab experience with protein interactions using biophysical biochemical and cell biological methods. Experience working with tissue processing protein oligomerization and antibody characterization in in vitro and ex vivo systems is preferred.
Technical Skills: You excel in biochemical methods such as protein production (from insect cells) purification ( HPLC - HIC SEC IEC IAC) Western blot ELISA or related immunoassays. You also have expertise in working with various cell culture models including primary neurons/iPSCs and techniques such as flow cytometry immunocyto/histochemistry including establishing functional assays such as ROS calcium & synapse working with omics technology is a plus but not a must.
Computational skills: Excellent data management and record keeping skills; Experience in Graphpad spotfire R python programming is preferred.
Communication: You can communicate write and present fluently in English.
Call to Action
Ready to take the next step in your career Were excited to see what youll bring to the team.
Apply now and upload your CV letters of recommendation and degree certificates to get started.
Who we are
A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver life-changing healthcare solutions that make a global impact.
Lets build a healthier future together.
Roche is an Equal Opportunity Employer.
Required Experience:
Staff IC
Key Skills
- Laboratory Experience
- Immunoassays
- Mammalian Cell Culture
- PCR
- Biochemistry
- Assays
- Cell Biology
- Research Experience
- Cell Culture
- Molecular Biology
- Flow Cytometry
- Western Blot
About Company
F. Hoffmann-La Roche AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel.
