Research Fellow, PGY1 Inner Ear Regeneration
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Job Location:
Boston, NH - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
Gene therapy and hair cell regeneration have shown great promise as new treatments for hearing loss that does not have any FDA approved drugs. One major obstacle to achieving treatment efficacy is our inability to deliver genes mRNA proteins and other molecules into the inner ear cell types efficiently. Dr. Wangs project is to test new delivery vehicles including viral and non-viral which can efficiently target diverse inner ear cell types with minimal toxicity. The other project is to optimize hair cell regeneration using human inner ear organoids with the potential for new treatment for hearing loss.Qualifications
Default Job Description
Additional Job Details (if applicable)
The research fellow will be responsible for performing modification of AAV and non-viral delivery vehicles (eg LNP) single cell RNAseq bioinformatics analysis to identify candidates in hair cell regeneration and synapse formation. She will test the delivery vehicles for DNA RNA and protein for inner ear cell types first in vitro followed by in vivo. She will conduct experiments to demonstrate the new delivery method together with new molecules identified will lead to functional restoration of hearing in mouse models of human genetic hearing loss. She will further conduct hair cell regeneration and synapse formation in human inner ear organoids with enhanced efficiency and optimize the drug-like cocktail for human application.
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EEO Statement:
Mass General Brigham Competency Framework
At Mass General Brigham our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance make hiring decisions identify development needs mobilize employees across our system and establish a strong talent pipeline.
Key Skills
- Bioinformatics
- Genetics
- R
- Biochemistry
- Cell Biology
- Research Experience
- Statistical Software
- Cell Culture
- Molecular Biology
- Data Analysis Skills
- Flow Cytometry
- Microscopy
About Company
Patients at Mass General have access to a vast network of physicians, nearly all of whom are Harvard Medical School faculty and many of whom are leaders within their fields.
