Principal Research Scientist, Lipid Chemistry
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Job Location:
Boston, NH - USA
Monthly Salary:
$ 120000 - 180000
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Job Description
General Summary:
The Principal Research Scientist Lipid Chemist for Non-Viral Delivery is self-reliant with a strong record of accomplishments independently identifying and solving tough problems repeatedly across a number of critical and diverse projects. The Principal Research Scientist innovates proficiently and generates insights that influence research strategies. Responsibilities will include the design and synthesis of lipids within a project. Demonstrates resourcefulness in running multiple activities concurrently all related to achievement of goals/objectives. Adapts to new projects rapidly and to multiple projects effectively ensuring alignment with corporate goals. The Principal Research Scientist is regarded as an emerging expert in a field of research providing reliable valuable advice to other research project teams and exhibits an ability to make significant conceptual contributions.
Key Duties and Responsibilities:
Design synthesize and characterize novel lipids and lipid libraries with therapeutically relevant properties for LNP-mediated gene delivery.
Designs and performs sophisticated technically challenging chemistry experiments efficiently and independently.
Distills complicated multidimensional data to clear hypotheses and sets new experimental directions.
Work closely with CRO collaborations to enhance and accelerate lipid library construction synthesis analysis and/or manufacturing.
Identifies broad implications to findings which transcend the immediate experiment.
Design synthesize and characterize unique conjugation handles for targeted gene delivery.
Makes substantive conceptual contributions to project activities and scientific strategies.
Maintain clear and complete ELN-based experimental records.
Present and share results with the broader team of scientists and cross-functional meetings.
Coordinates patent and publication preparation.
Knowledge and Skills:
Demonstrates advanced judgement balancing technical feasibility and scientific opportunity/impact.
A strong track record of developing medicinal chemistry-based approaches to design and synthesize novel lipid libraries.
Demonstrated exemplary skills in all aspects of modern organic and medicinal chemistry including data analysis parallel library design and synthesis structure-based design and analytical and purification methods.
Well oriented with lipid LNP and non-viral gene delivery related literature and progress.
Discerns new productive paths in experiments with greater regularity.
Well versed with different bioconjugation strategies and optimizations thereof for proteins/peptides antibodies lipids LNPs oligonucleotides and other biomolecules.
Extensive experience implementing routine and advanced analytical methods to characterize structures and purities of synthetic compounds including but not limited to HPLC-CAD LC/MS NMR.
In-depth experience in various purification techniques including various liquid chromatography methods (e.g. RP IEX SEC HIC affinity FPLC) and membrane filtrations.
A superior communicator demonstrating the ability to write advanced technical documents and demonstrating confidence and versatility in presenting verbally to diverse audiences.
Education and Experience:
PhD (or equivalent degree) in chemistry or related science and 4-7 years of relevant post-doctoral employment experience or
Masters degree (or equivalent degree) in chemistry or related science and 7 years of relevant employment experience or
Bachelors degree (or equivalent degree) in chemistry or related science and 10 yr relevant employment experience.
Pay Range:
$120000 - $180000Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors including skills competencies experience and other job-related factors permitted by law.
At Vertex our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career financial family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter) educational assistance programs including student loan repayment a generous commuting subsidy matching charitable donations 401(k) and so much more.
Flex Designation:
On-Site DesignatedFlex Eligibility Status:
In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at
Required Experience:
Staff IC
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
About Company
Vertex Pharmaceuticals invests in scientific innovation to create transformative medicines for people with serious diseases.
