Principal Scientist â Oligonucleotide Chemistry
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Job Location:
Thousand Oaks, CA - USA
Monthly Salary:
$ 170382 - 170382
Posted on:
11-09-2025
Vacancies:
1 Vacancy
Job Summary
Career Category
ScientificJob Description
Join Amgens Mission of Serving Patients
At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.
Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.
Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Principal Scientist
What you will do
Lets do this. Lets change the this vital role you will use your experimental background in oligonucleotide chemistry and biochemistry to design synthesize and optimize therapeutic RNA oligonucleotides to directly support the pre-clinical pipeline within Amgen.
Hands-on laboratory role for the in-house development and optimization of oligonucleotide synthesis and analytical methods
Conjugation of lipids carbohydrates and other building blocks to be used for therapeutic oligonucleotide delivery
Lead internal and external cross-discipline collaborations to advance an RNA therapeutic preclinical pipeline including mentoring junior scientists
Liaise with external CRO partners to implement and scale synthetic methodologies
Contribute to overall strategy including intellectual property planning and competitive landscape assessment
What we expect of you
We are all different yet we all use our unique contributions to serve patients. The professional we seek is a chemist with these qualifications.
Basic Qualifications:
PhD and 2 years of relevant industry experience
Masters degree and 5 years of relevant industry experience
Bachelors degree and 7 years of relevant industry experience
Preferred Qualifications:
Leadership/mentoring experience
Ability to effectively communicate within cross-functional teams
Experience managing and developing relationships with external vendors
What you can expect of us
As we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.
In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:
A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accounts
A discretionary annual bonus program or for field sales representatives a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models including remote and hybrid work arrangements where possible
Apply now and make a lasting impact with the Amgen team.
In any materials you submit you may redact or remove age-identifying information such as age date of birth or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.
.Salary Range
146210.00 USD - 170382.00 USDRequired Experience:
Staff IC
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
About Company
Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the ... View more
