Clinical-Scientific - Bench Scientist
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Job Location:
Bothell, WA - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
Job Summary:-
Looking for an experienced Scientist to join our ADC Characterization team within the Protein Solutions and Bioanalytical department. This role offers a unique opportunity to contribute to the development of life-changing antibody-based cancer therapeutics. The ideal candidate will be a hands-on expert in LC-MS and protein analysis with a passion for scientific problem-solving and a drive to innovate. Youll lead method development for the analysis of intact antibodies antibody-drug conjugates (ADCs) and other bioconjugates while also maintaining and enhancing our mass spectrometry infrastructure.
Key Responsibilities
- Develop optimize and implement LC-MS methods for intact protein and ADC characterization
- Perform in-depth peptide mapping to characterize proteins and bioconjugates
- Develop fit-for-purpose assays to quantify and characterize proteins in complex biological matrices (e.g. rodent plasma)
- Maintain and troubleshoot shared LC-MS instruments (Waters Thermo Sciex)
- Train and support scientists on instrument use method application and best practices
- Provide consultative scientific and technical guidance to non-MS users
- Analyze and interpret complex MS data; prepare comprehensive technical reports and presentations
- Stay current with scientific literature and apply innovative technologies and methodologies
- Work cross-functionally with Conjugation Chemistry and Antibody Design teams
- Contribute to continuous improvement and automation of mass spec workflows
Required Qualifications
- Ph.D. (or equivalent experience) in Analytical Chemistry Biochemistry Bioanalytical Chemistry Pharmaceutical Sciences or a related field
- 4 years of hands-on experience in mass spectrometry for large molecule/protein characterization (industry or academic)
- Proven expertise in operating and maintaining QTOF and Orbitrap-based mass spectrometers
- Deep understanding of protein and antibody structure conjugation chemistry and post-translational modifications
- Experience with peptide mapping and intact mass analysis
- Strong critical thinking and problem-solving skills
- Excellent documentation practices and attention to detail
- Ability to work independently and collaboratively in a team-based environment
Preferred Qualifications
- Experience with:
- Waters Xevo G2S QTOF
- Thermo Q Exactive
- Sciex X500B or ZenoTOF 7600
- Knowledge of Protein Metrics software for data analysis and high-throughput reporting
- Experience with affinity purification and SEC-MALS techniques
- Expertise in identifying post-translational modifications (PTMs) or enzymatic modifications
- Experience with Hydrogen/Deuterium Exchange (HDX-MS) or protein conformational analysis
- Familiarity with automation in LC-MS workflows
Key Skills
- Laboratory Experience
- Immunoassays
- Machine Learning
- Biochemistry
- Assays
- Research Experience
- Spectroscopy
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Data Analysis Skills
