Associate Principal Scientist, Downstream Process Research & Development
Associate Principal Scientist, Downstream Process Research & Development
Employer Active
Job Alert
You will be updated with latest job alerts via email
Share
Job Alert
You will be updated with latest job alerts via email
$ 139600 - 219700
1 Vacancy
Job Description
Job Description
Associate Principal Scientist
The Biologics Process Research & Development organization within our companys Research Laboratories is responsible for developing the drug substance manufacturing processes for our companys biologics pipeline. We work closely with colleagues in Discovery Pre-clinical and Early Development to rapidly develop manufacturing processes for diverse biotherapeutics and efficiently manufacture material to supply clinical trials. We are also responsible for commercial process development and the development and implementation of new manufacturing technologies. We work with our partners in the companys Manufacturing Division to commercialize and launch new products.
We are seeking a highly motivated and experienced individual to join our Downstream Process Development and Engineering group as an Associate Principal this role you will work with a highly collaborative team of Scientists and Engineers to design and develop downstream purification processes in support of early and late-stage biological products. The scope and activities include designing and optimization of downstream unit operations such as cell harvest filtration chromatography viral clearance precipitation crystallization and continuous processing for batch and intensified/continuous bioprocesses. The role will also include strategic Applicants should have effective organizational and multi-tasking skills and strong communication skills both verbal and presentation of data is required. A track record of leveraging data science and digital tools for delivering impactful solutions to complex problems are distinguishing. Evidence of strong cross-functional collaboration experience successfully mentoring junior scientists leading projects and an external presence through scientific excellence are expected.
Job responsibilities:
The successful candidate will contribute to CMC development of our companys pipeline playing an active role in development of downstream processes and transfer to clinical and commercial manufacturing sites. She/He will also develop strategies for process and pipeline-facing innovation.
Responsibilities include:
Leading biologic downstream process development for first-in-human and commercial processes by efficiently developing high yield robust and scalable processes. Independently designing and conducting experiments using relevant operational parameters and analytical inputs.
Providing technical supervision for process development and characterization
Collaborate with upstream process development Biologics Analytical R&D and other cross-functional teams in both Research and Manufacturing to advance biologics pipeline.
Advancing downstream platform process technical strategy and championing creative process improvement initiatives
Assessing new technologies sciences and industry strategies and relevance to our company
Collaborating with academia industry partners and vendors to drive development innovation and adoption of new process technologies
Keeping up to date with the external patent and literature environment; actively presents and publishes externally and pursues patenting strategies
Mentoring junior scientists
Education requirements:
Ph.D. with 3 years of industry experience or Master with 6 years industry experience or BS with 8 years in industry experience in Chemical Engineering Biochemical engineering or a related field
Required skills:
Proven record of accomplishments in downstream process and technology development with a scientific publication and presentation track record.
Scientific understanding of the engineering principles for recombinant protein purification unit operations. Proven ability to design and execute protein purification experiments independently.
Ability to direct the planning execution analysis and documentation of all stages of downstream process development.
Ability to work in a matrixed team environment and collaborate with both internal and external partners including vendors
Knowledge of biologics CMC development cycle
Demonstrated ability for taking initiative creativity and innovation in problem solving
Preferred skills:
Experience with high throughput experimentation using automation platforms such as TECAN
Experience using and/or programming process control systems such as DeltaV and PCS 7
Experience with integrated and continuous processing and equipment including multi-column chromatography systems (BioSMB PCC or similar)
Background or experience in data science approaches related to downstream processes and predictive modeling (multivariate data analysis machine learning/artificial intelligence leveraging PAT)
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race color age religion sex sexual orientation gender identity national origin protected veteran status disability status or other applicable legally protected a federal contractor we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws visit:
We are proud to be a company that embraces the value of bringing together talented and committed people with diverse experiences perspectives skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas broad experiences backgrounds and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one anothers thinking and approach problems collectively.
Learn more about your rights including under California Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.
The salary range for this role is
$139600.00 - $219700.00This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive if applicable.
We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.
Employee Status:
RegularRelocation:
VISA Sponsorship:
Travel Requirements:
Flexible Work Arrangements:
Not ApplicableShift:
Valid Driving License:
Hazardous Material(s):
Required Skills:
Cell Line Development Communication Detail-Oriented Downstream Process Development Drug Delivery Technology Drug Development Expression Vectors Interpersonal Relationships Leading Project Teams Molecular Biology Pharmaceutical Formulations Pharmaceutical Process Development Physical Characterization Science Social Collaboration Stable Cell Lines Strategic PlanningPreferred Skills:
Job Posting End Date:
09/26/2025*A job posting is effective until 11:59:59PM on the day BEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Required Experience:
Staff IC
Employment Type
Full-Time
