Principal Scientist - ADC Pharmacology
Principal Scientist - ADC Pharmacology
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$ 102900 - 171500
1 Vacancy
Job Description
Use Your Power for Purpose
At Pfizer our purpose is to deliver breakthroughs that change patients lives. Your work will directly impact the development of therapies and vaccines that improve patients lives globally. By leveraging advanced science and cutting-edge technologies you will play a crucial role in transforming innovative ideas into life-changing medical solutions. Whether you are involved in discovery sciences ensuring drug safety and efficacy or supporting clinical trials your contributions will be vital in accelerating the delivery of top-tier medicines to patients worldwide.
What You Will Achieve
The Pfizer Oncology Research Unit is seeking a Principal Scientist to join our ADC Pharmacology team. The candidate will join an interdisciplinary and highly collaborative team to support and advance our preclinical ADC pipeline. The ideal candidate will have a strong background in cell and molecular biology in vitro pharmacology and automating the drug discovery process.
In this role you will:
Develop and Standardize ADC Screening Assays: Design optimize and validate in vitro screening assays to evaluate the mechanism of action of ADCs and ADC payloads.
Implement and Optimize Automation Processes: Develop implement and continuously improve automated screening processes to enhance efficiency accuracy and throughput for ADC screening. This includes integrating robotics software and data management systems to streamline workflows and reduce manual intervention.
Collaborate with Cross-Functional Teams: Work closely with other scientists researchers and departments to ensure the successful progression of ADC projects.
Manage CRO Partnerships: Oversee and coordinate with Contract Research Organizations (CROs) to develop and execute ADC screening programs. This includes defining project scopes ensuring adherence to timelines and budgets and quality control.
Mentor and Train Junior Staff: Provide guidance and training to junior scientists and technicians in ADC screening techniques and best practices.
Stay Current with Industry Trends: Keep up to date with the latest advancements in ADC technology and screening methodologies to ensure the company remains at the forefront of the field.
Prepare and Present Reports: Compile comprehensive reports and present findings to stakeholders including senior management and external partners.
Here Is What You Need (Minimum Requirements)
BS with at least 12 years of experience or MS with at least 9 years of experience or PhD with at least 4 years of experience.
Expertise in a variety of cell-based assays and technologies including luminescence-based cell viability/cytotoxicity assays HTRF AlphLISA HiBiT and imaging.
Experience in the development and standardization of in vitro cell-based screening assays to facilitate lead selection including establishment of metrics and acceptance criteria for monitoring assay performance.
Experience automating drug discovery workflows.
Experience managing an independent research program with minimal supervision.
Demonstrated ability tolead and inspire a diverse team fostering a culture of accountability collaboration and continuous improvement to achieve goals.
Strong problem-solving skills and the ability to apply novel and innovative approaches.
Strong oral and written communication skills.
Must be goal-oriented with the ability to handle multiple tasks and to prioritize.
Bonus Points If You Have (Preferred Requirements)
PhD with 4 years of relevant industry experience.
Previous experience with ADCs and hands-on knowledge of the drug discovery process.
Experience managing screening projects at CROs.
Direct managerial experience in an industry research setting.
PHYSICAL/MENTAL REQUIREMENTS
Lifting sitting standing walking bending ability to perform laboratory work and complex data analysis.
NON-STANDARD WORK SCHEDULE TRAVEL OR ENVIRONMENT REQUIREMENTS
Working in a BSL-2 laboratory environment with appropriate personal protective equipment.
Additional Information:
- Work Location Assignment:On Premise
- Last Day to Apply: August 22 2025
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race color religion sex sexual orientation age gender identity or gender expression national origin disability or veteran status. Pfizer also complies with all applicable national state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Required Experience:
Staff IC
Employment Type
Full-Time
